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Quantification of myocardial blood flow with 11C-hydroxyephedrine dynamic PET: comparison with 15O-H2O PET

  • Original Article
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Journal of Nuclear Cardiology Aims and scope

Abstract

Background

11C-hydroxyephedrine (HED) PET has been used to evaluate the myocardial sympathetic nervous system (SNS). Here we sought to establish a simultaneous approach for quantifying both myocardial blood flow (MBF) and the SNS from a single HED PET scan.

Methods

Ten controls and 13 patients with suspected cardiac disease were enrolled. The inflow rate of 11C-HED (K1) was obtained using a one-tissue-compartment model. We compared this rate with the MBF derived from 15O-H2O PET. In the controls, the relationship between K1 from 11C-HED PET and the MBF from 15O-H2O PET was linked by the Renkin-Crone model.

Results

The relationship between K1 from 11C-HED PET and the MBF from 15O-H2O PET from the controls’ data was approximated as follows: K1  =  (1 − 0.891 * exp(− 0.146/MBF)) * MBF. In the validation set, the correlation coefficient demonstrated a significantly high relationship for both the whole left ventricle (r = 0.95, P < 0.001) and three coronary territories (left anterior descending artery: r = 0.96, left circumflex artery: r = 0.81, right coronary artery: r =  0.86; P < 0.001, respectively).

Conclusion

11C-HED can simultaneously estimate MBF and sympathetic nervous function without requiring an additional MBF scan for assessing mismatch areas between MBF and SNS.

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Abbreviations

HED:

Hydroxyephedrine

HR:

Heart rate

K1:

Inflow rate of 11C-HED

LV:

Left ventricle

MBF:

Myocardial blood flow

PET:

Positron emission tomography

RI:

Retention index

rMBFs:

3-coronary-regional MBFs

ROI:

Region of interest

SNS:

Sympathetic nervous system

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Acknowledgements

We thank Shigeo Oomagari, MSc, and Eriko Suzuki for their support to this study.

Disclosure

All authors have no conflicts of interest to disclose.

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Authors and Affiliations

  1. Faculty of Health Sciences, Hokkaido University Graduate School of Medicine, Sapporo, Japan

    Yuji Hiroshima BSC & Chietsugu Katoh MD, PhD

  2. Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, N15 W7, Kita-Ku, Sapporo, 060-8638, Hokkaido, Japan

    Osamu Manabe MD, PhD, Yuuki Tomiyama PhD, Kenji Hirata MD, PhD, Markus Kroenke MD & Nagara Tamaki MD, PhD

  3. Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan

    Masanao Naya MD, PhD, Masahiko Obara MD, PhD & Tadao Aikawa MD

  4. Division of Medical Imaging and Technology, Hokkaido University Hospital, Sapporo, Japan

    Keiichi Magota PhD

  5. Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan

    Noriko Oyama-Manabe MD, PhD

  6. Diagnostic and Therapeutic Nuclear Medicine, National Institute of Radiological Science, Chiba, Japan

    Keiichiro Yoshinaga MD, PhD

  7. Department of Nuclear Medicine, Klinikumrechts der Isar, Technical University of Munich, Munich, Germany

    Markus Kroenke MD

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  1. Yuji Hiroshima BSC
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  2. Osamu Manabe MD, PhD
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  12. Nagara Tamaki MD, PhD
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  13. Chietsugu Katoh MD, PhD
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Correspondence to Osamu Manabe MD, PhD.

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Hiroshima, Y., Manabe, O., Naya, M. et al. Quantification of myocardial blood flow with 11C-hydroxyephedrine dynamic PET: comparison with 15O-H2O PET. J. Nucl. Cardiol. 27, 1118–1125 (2020). https://doi.org/10.1007/s12350-017-1140-4

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