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EUS-guided needle biopsy for autoimmune pancreatitis

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Abstract

Endoscopic ultrasound (EUS)-guided fine needle aspiration (FNA), though a well-established method for specimen acquisition from pancreatic neoplasm, has a limited role for non-focal benign pancreatic diseases such as autoimmune pancreatitis (AIP) due to sample inadequacy and architectural distortion. Core biopsies through EUS-trucut biopsy (EUS-TCB) or newer generation EUS-fine needle biopsy (EUS-FNB) enable better histopathologic review through greater tissue specimen size and visualization of the histologic milieu. We systematically reviewed EUS-guided sample acquisition (FNA or core biopsy) and the role of EUS-guided needle biopsy in evaluation of AIP. EUS-guided needle biopsy provided significantly higher adequacy of specimen (96.8% vs 79.8%; p = 0.016) and higher diagnostic sensitivity (60.20% vs 42.02%; p < 0.0001) compared to EUS-FNA for AIP. More evidence is imperative in evaluating the feasibility, safety, and diagnostic utility of EUS-guided needle biopsy for AIP.

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Authors and Affiliations

  1. Department of Internal Medicine, Yale New Haven Health System-Bridgeport Hospital, Bridgeport, CT, USA

    Ankit Chhoda

  2. Division of Gastroenterology and Hepatology, University of New Mexico, MSC10 5550, 1 University of New Mexico, Albuquerque, NM, 87131, USA

    Tarun Rustagi

Authors
  1. Ankit Chhoda
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All authors contributed equally to this work.

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Correspondence to Tarun Rustagi.

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Ankit Chhoda and Tarun Rustagi declare that they have no conflict of interest.

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Chhoda, A., Rustagi, T. EUS-guided needle biopsy for autoimmune pancreatitis. Clin J Gastroenterol 13, 669–677 (2020). https://doi.org/10.1007/s12328-020-01153-0

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  • DOI: https://doi.org/10.1007/s12328-020-01153-0

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