Skip to main content
SpringerLink
Log in

Endoscopic resection of gangliocytic paraganglioma of the duodenum: a case report

  • Case Report
  • Published:
Clinical Journal of Gastroenterology Aims and scope Submit manuscript

Abstract

Duodenal gangliocytic paragangliomas are extremely rare. A 79-year-old woman underwent gastrointestinal endoscopy for screening prior to resection of gallbladder carcinoma. Gastrointestinal endoscopy revealed a 5-mm submucosal tumor in the second portion of the duodenum. Contrast-enhanced computed tomography revealed no tumor or metastasis. Endoscopic ultrasonography revealed low echo pattern of the tumor. Histopathological examination of the biopsy specimen revealed proliferation of three types of cells (epithelioid cells, spindle cells, and ganglion cells). Immunohistochemical examination revealed that the tumor was positive for S-100 and synaptophysin. The preoperative diagnosis was gangliocytic paraganglioma. The tumor was completely resected by endoscopic mucosal resection (EMR). In conclusion, an early stage of gangliocytic paraganglioma of the duodenum could be resected using EMR.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7

Similar content being viewed by others

References

  1. Scheithauer BW, Nora FE, LeChago J, et al. Duodenal gangliocytic paraganglioma. Clinicopathologic and immunocytochemical study of 11 cases. Am J Clin Pathol. 1986;86:559–65.

    Article  CAS  Google Scholar 

  2. Okubo Y, Nemoto T, Wakayama M, et al. Gangliocytic paraganglioma: a multi-institutional retrospective study in Japan. BMC Cancer. 2015;15:269.

    Article  Google Scholar 

  3. Lin D, Hu Y, Xing X, et al. Pulmonary gangliocytic paraganglioma: a case report and review of the literature. Int J Clin Exp Pathol. 2014;7:432–7.

    PubMed  Google Scholar 

  4. Dahl EV, Waugh JM, Dahlin DC. Gastrointestinal ganglioneuromas; brief review with report of a duodenal ganglioneuroma. Am J Pathol. 1957;33:953–65.

    CAS  PubMed  PubMed Central  Google Scholar 

  5. Okubo Y, Yoshioka E, Suzuki M, et al. Diagnosis, pathological findings, and clinical management of gangliocytic paraganglioma: a systematic review. Front Oncol. 2018;8:291.

    Article  Google Scholar 

  6. Okubo Y, Yokose T, Tuchiya M, et al. Duodenal gangliocytic paraganglioma showing lymph node metastasis: a rare case report. Diagn Pathol. 2010;5:27.

    Article  Google Scholar 

  7. Dookhan DB, Miettinen M, Finkel G, et al. Recurrent duodenal gangliocytic paraganglioma with lymph node metastases. Histopathology. 1993;22:399–401.

    Article  CAS  Google Scholar 

  8. Henry C, Ghalel-Mechaoui H, Bottero N, et al. Gangliocytic paraganglioma of the pancreas with bone metastasis. Ann Chir. 2003;128:336–8.

    Article  CAS  Google Scholar 

  9. Park SJ, Kim DH, Lim H, et al. Endoscopic resection as a possible radical treatment for duodenal gangliocytic paraganglioma: a report of four cases. Korean J Gastroenterol. 2014;63:114–9.

    Article  Google Scholar 

  10. Okubo Y, Wakayama M, Nemoto T, et al. Literature survey on epidemiology and pathology of gangliocytic paraganglioma. BMC Cancer. 2011;11:187.

    Article  Google Scholar 

  11. Perrone T, Sibley RK, Rosai J. Duodenal gangliocytic paraganglioma. An immunohistochemical and ultrastructural study and a hypothesis concerning its origin. Am J Surg Pathol. 1985;9:31–41.

    Article  CAS  Google Scholar 

  12. Burke AP, Helwig EB. Gangliocytic paraganglioma. Am J Clin Pathol. 1989;92:1–9.

    Article  CAS  Google Scholar 

  13. Plaza JA, Vitellas K, Marsh WL Jr. Duodenal gangliocytic paraganglioma: a radiological-pathological correlation. Ann Diagn Pathol. 2005;9:143–7.

    Article  Google Scholar 

  14. Watanabe K, Hasegawa H, Sakuma H, et al. Two cases of duodenal gangliocytic paraganglioma: immunocytochemical characteristics. Fukushima J Med Sci. 1995;41:141–52.

    CAS  PubMed  Google Scholar 

  15. Park HK, Han HS. Duodenal gangliocytic paraganglioma with lymph node metastasis. Arch Pathol Lab Med. 2016;140:94–8.

    Article  CAS  Google Scholar 

  16. Matsubayashi H, Ishiwatari H, Matsui T, et al. Gangliocytic paraganglioma of the minor papilla of the duodenum. Intern Med. 2017;56:1029–35.

    Article  Google Scholar 

  17. Yang M, Leighton JA, Faigel DO, et al. Duodenal gangliocytic paraganglioma: endoscopy, sonography and F-18 FDG PET/CT imaging. Dig Liver Dis. 2017;49:1162.

    Article  Google Scholar 

  18. Cathcart SJ, Sasson AR, Kozel JA, et al. Duodenal gangliocytic paraganglioma with lymph node metastases: a case report and comparative review of 31 cases. World J Clin Cases. 2017;5:222–33.

    Article  Google Scholar 

  19. Nagai T, Torishima R, Nakashima H, et al. Duodenal gangliocytic paraganglioma treated with endoscopic hemostasis and resection. J Gastroenterol. 2004;39:277–83.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Gastroenterology, Aichi Medical University School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan

    Masahide Ebi, Tomoko Ochiai, Tomoya Sugiyama, Kazuhiro Yamamoto, Kazunori Adachi, Yoshiharu Yamaguchi, Yasuhiro Tamura, Shinya Izawa, Yasutaka Hijikata, Sayuri Yamamoto, Yasushi Funaki, Naotaka Ogasawara, Makoto Sasaki & Kunio Kasugai

Authors
  1. Masahide Ebi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Tomoko Ochiai
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Tomoya Sugiyama
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Kazuhiro Yamamoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Kazunori Adachi
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Yoshiharu Yamaguchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Yasuhiro Tamura
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Shinya Izawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Yasutaka Hijikata
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Sayuri Yamamoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Yasushi Funaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Naotaka Ogasawara
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Makoto Sasaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. Kunio Kasugai
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Masahide Ebi.

Ethics declarations

Conflict of interest

Masahide Ebi, Tomoko Ochiai, Tomoya Sugiyama, Kazuhiro Yamamoto, Kazunori Adachi, Yoshiharu Yamaguchi, Yasuhiro Tamura, Shinya Izawa, Yasutaka Hijikata, Sayuri Yamamoto, Yasushi Funaki, Naotaka Ogasawara, Makoto Sasaki, and Kunio Kasugai declare that they have no conflict of interest.

Human/animal rights

All the procedures followed have been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

Informed consent

Informed consent was obtained from all patients for being included in the study.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ebi, M., Ochiai, T., Sugiyama, T. et al. Endoscopic resection of gangliocytic paraganglioma of the duodenum: a case report. Clin J Gastroenterol 13, 203–208 (2020). https://doi.org/10.1007/s12328-019-01043-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12328-019-01043-0

Keywords

Search

Navigation