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Long-term survival after resection of brain metastases from esophagogastric junction adenocarcinoma: report of two cases and review of the literature

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Abstract

The prognosis for brain metastasis from primary esophageal or gastric cancer is often poor because of late detection and a lack of effective treatments. We encountered two cases of long-term survival after resection of brain metastasis that was detected >1 year after primary esophagogastric junction adenocarcinoma resection. Both patients underwent total gastrectomy, middle to lower esophagectomy, and Roux-en-Y reconstruction using the jejunum, and intrathoracic anastomosis was performed via right thoracotomy and laparotomy for primary tumor resection as well as brain metastasis resection followed by CyberKnife irradiation. They remained recurrence free—one remains alive after 6.5 years, while the other died of myocardial infarction 4 years after surgery. The present cases emphasize that long-term survival in patients with brain metastasis from gastric cancer can be expected after resection and stereotactic radiosurgery of brain metastasis detected >1 year after the resection of primary gastric adenocarcinoma.

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Acknowledgments

We are grateful to Yuzo Uchida, Professor Emeritus of Faculty of Medicine, Oita University, for his support in carrying out this case study.

Disclosures

Conflict of Interest: There are no financial or other relations that could lead to a conflict of interest.

Human/Animal Rights: All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008(5).

Informed Consent: Informed consent was obtained from all patients for being included in the study.

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Authors and Affiliations

  1. Department of Surgery, Jikeikai Nishida Hospital, 2-266, Tsuruoka Nishimachi, Saiki-shi, Oita, 876-0047, Japan

    Mototsugu Matsunaga, Katsuhisa Harada & Kazuki Okamura

  2. Oita University Hospital Emergency and Critical Care Center, Oita, Japan

    Shinsuke Wada

  3. Department of Diagnostic Pathology, Faculty of Medicine, Oita University, Oita, Japan

    Tsutomu Daa

  4. Department of Surgery, Center for Community Medicine, Faculty of Medicine, Oita University, Oita, Japan

    Tsuyoshi Noguchi

Authors
  1. Mototsugu Matsunaga
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  2. Shinsuke Wada
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  3. Tsutomu Daa
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  4. Katsuhisa Harada
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  5. Kazuki Okamura
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  6. Tsuyoshi Noguchi
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Correspondence to Mototsugu Matsunaga.

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Matsunaga, M., Wada, S., Daa, T. et al. Long-term survival after resection of brain metastases from esophagogastric junction adenocarcinoma: report of two cases and review of the literature. Clin J Gastroenterol 7, 213–218 (2014). https://doi.org/10.1007/s12328-014-0491-5

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  • DOI: https://doi.org/10.1007/s12328-014-0491-5

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