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Exploration and Identification of Cortico-Cerebellar-Brainstem Closed Loop During a Motivational-Motor Task: an fMRI Study

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Abstract

The cerebellum is involved not only in motor coordination, training, and memory, but also in cognition and emotion. Lobule VI in particular belongs to sensorimotor, salience, and executive cerebellar networks. This study aims to determine whether lobule VI would constitute an integrative interface between motor and cognitive/emotional circuits during a motor task with verbal encouragement, likely in conjunction with the basal ganglia (reward and motivational system). We used fMRI to identify specific recruitment of cerebellar and striatal systems during physical performance using two motor tasks with and without encouragement. We found that: (i) Force results were higher during verbal encouragement than during basal condition in all participants. (ii) The anterior part of the right lobule VI was activated by motor execution in both tasks, while its posterior part was specifically activated by verbal encouragement. (iii) The closed-connectivity loop maintained motivation induced by verbal encouragement between cerebral and cerebellar through the red nucleus and striatal network. Therefore, right lobule VI is a hub-controlling sensorimotor and motivates aspects of motor performance in relation with the red nucleus and the ventral striatum. These results could have important implications for extrapyramidal and multisystem degenerative diseases.

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Acknowledgments

We would like to thank the participants that gave their time to take part in this study and everybody who has contributed to its realization

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Authors and Affiliations

  1. Laboratoire CeRSM (EA 2931), Equipe “Analyse du Mouvement en Biomécanique, Physiologie et Imagerie”. UFR STAPS, Université Paris Ouest Nanterre La Défense, 200 avenue de la République, 92000, Nanterre, France

    Chama Belkhiria, Tarak Driss, Hamdi Jaafar & Giovanni de Marco

  2. Service de Neuro-Imagerie, Hôpital des Quinze-Vingts, UPMC Paris 6, 28, rue de Charenton, 75012, Paris, France

    Christophe Habas

  3. Assistance Publique-Hôpitaux de Paris, Groupe hospitalier la Pitié Salpêtrière, service de Neuro-Radiologie, Paris, France

    Remy Guillevin

Authors
  1. Chama Belkhiria
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  2. Tarak Driss
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  3. Christophe Habas
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  4. Hamdi Jaafar
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  5. Remy Guillevin
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  6. Giovanni de Marco
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Corresponding author

Correspondence to Chama Belkhiria.

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The study was approved by the local ethics committee.

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The authors declare that they have no conflicts of interest.

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Belkhiria, C., Driss, T., Habas, C. et al. Exploration and Identification of Cortico-Cerebellar-Brainstem Closed Loop During a Motivational-Motor Task: an fMRI Study. Cerebellum 16, 326–339 (2017). https://doi.org/10.1007/s12311-016-0801-1

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  • DOI: https://doi.org/10.1007/s12311-016-0801-1

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