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Mutations in HNF1A Gene are not a Common Cause of Familial Young-Onset Diabetes in Iran

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Abstract

Mutations in hepatocyte nuclear factor-1 alpha (HNF1A) as a homeodomain transcription factor which regulates variety of genes, are the most common cause of maturity-onset diabetes of the young (MODY). Detection of HNF1A mutations not only classifies the subtype, but also predicts the likely clinical course and may alters the method of treatment from insulin to the oral sulphonylureas, which is shown to improve glycemic control. The coding and promoter regions of HNF1A gene were screened for mutations in 34 unrelated Iranian MODY patients. We identified one novel missense mutation (C49G) and two novel polymorphisms and 8 recently identified SNPs in the HNF1A gene. It is possible that in Iran, other yet to be identified genes are responsible for the familial young onset diabetes. Hence, there is a need for more extensive genetic analyses in Iranian patients with familial young onset diabetes.

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Acknowledgements

This study was supported by grants from Mashhad University of Medical Sciences Research Grant Committee (Code: 87350).

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Authors and Affiliations

  1. North Khorasan University of Medical Sciences, Bojnurd, Iran

    Meysam Moghbeli

  2. Medical Genetics Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Bahram Naghibzadeh, Martha Ghahraman & Mohammad Reza Abbaszadegan

  3. Division of Human Genetics, Immunology Research Center, Avicenna Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran

    Martha Ghahraman & Mohammad Reza Abbaszadegan

  4. Immunogenetics Department, Immunology Research Center, Bu-Ali Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Sedigheh Fatemi

  5. Endocrinology and Metabolism Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Morteza Taghavi

  6. Department of Pediatric Endocrinology, School of Medicine, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

    Rahim Vakili

Authors
  1. Meysam Moghbeli
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  2. Bahram Naghibzadeh
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  3. Martha Ghahraman
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  4. Sedigheh Fatemi
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  5. Morteza Taghavi
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  6. Rahim Vakili
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  7. Mohammad Reza Abbaszadegan
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Corresponding authors

Correspondence to Rahim Vakili or Mohammad Reza Abbaszadegan.

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The authors declare that they have no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Moghbeli, M., Naghibzadeh, B., Ghahraman, M. et al. Mutations in HNF1A Gene are not a Common Cause of Familial Young-Onset Diabetes in Iran. Ind J Clin Biochem 33, 91–95 (2018). https://doi.org/10.1007/s12291-017-0648-3

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  • DOI: https://doi.org/10.1007/s12291-017-0648-3

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