Skip to main content

Advertisement

SpringerLink
Log in

Bone Marrow Metastasis in a Suspected Case of Angiosarcoma Unravelled by Immunohistochemistry

  • Images
  • Published:
Indian Journal of Hematology and Blood Transfusion Aims and scope Submit manuscript

Abstract

A 40-year-old female presented with progressive fatigue and left upper abdominal discomfort for 1 month. CT scan revealed ill-defined hypervascular lesions in the liver and diffuse enlargement of the spleen. She had severe anemia with leukoerythroblastic reaction. Bone marrow smears revealed clusters and discrete spindle cells, few plump and round cells. Trephine biopsy revealed an infiltrative spindle-cell neoplasm replacing the marrow with the focal presence of epithelioid cell clusters. On immunostaining, the tumor cells were positive for CD34, CD31, Friend Leukemia Virus Integration-1 (FLI1), and vimentin, consistent with metastatic angiosarcoma. There were multiple small aggregates of 5–10 MIB-1 positive tumor cells (overall positivity < 1%). She succumbed to her illness before initiation of any therapy. Bone marrow metastasis of angiosarcoma is extremely rare. The aggressive clinical course and judicious use of immunohistochemical markers are required for definitive diagnosis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Deyrup AT, Miettinen M, North PE, Khoury JD, Tighiouart M, Spunt SL et al (2009) Angiosarcomas arising in the viscera and soft tissue of children and young adults: a clinicopathologic study of 15 cases. Am J Surg Pathol 33(2):264–269

    Article  Google Scholar 

  2. Levy ACJ, DeFilipp M, Blakely M, Asiry S, Jormark S, Goodman A (2019) Splenic angiosarcoma diagnosed on bone marrow biopsy: case report and literature review. Radiol Case Rep 14:390–395

    Article  Google Scholar 

Download references

Funding

The authors declare no financial support for this study.

Author information

Authors and Affiliations

  1. Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India

    Saniya Sharma & Man Updesh Singh Sachdeva

  2. Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India

    Pulkit Rastogi

  3. Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India

    Nidhi Prabhakar

Authors
  1. Saniya Sharma
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Man Updesh Singh Sachdeva
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Pulkit Rastogi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Nidhi Prabhakar
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

Data collection and processing: SS, MUSS; Analysis: SS, MUSS, PR; Literature search: SS, MUSS, PR, writing: SS, MUSS; radiological diagnosis: NP. All authors reviewed and approved the final manuscript.

Corresponding author

Correspondence to Man Updesh Singh Sachdeva.

Ethics declarations

Conflict of interest

The authors declare no conflict of interest in this study.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sharma, S., Sachdeva, M.U.S., Rastogi, P. et al. Bone Marrow Metastasis in a Suspected Case of Angiosarcoma Unravelled by Immunohistochemistry. Indian J Hematol Blood Transfus 38, 432–433 (2022). https://doi.org/10.1007/s12288-021-01501-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12288-021-01501-1

Keywords

Search

Navigation