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PD-L1-driven efficient enrichment and elimination of circulating cancer cells by magnetic MoSe2 nanosheet

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Abstract

Circulating tumor cells (CTCs) are important biomarkers in the development and progression of lung cancer because they can reach other organs through the blood circulation and form distant metastases, exacerbating lung cancer progression. The presence of CTCs is also the main reason for the failure of nanomedicine-based lung cancer treatments. Therefore, magnetic MoSe2 nanosheets loaded with programmed death-ligand 1 (PD-L1), named PD-L1-MFP NS, were employed here to precisely capture lung cancer CTCs in the blood circulation through the tumor-targeting effect of PD-L1 killing CTCs with highly effective photothermal therapy (PTT). In addition, by increasing the expression of cytomegalovirus UL16-binding protein (ULBP) ligands on tumor cells, the PD-L1-MFP NS further activated natural killer (NK) cells and triggered NK cell-induced cancer immunotherapy, thereby enhancing the overall tumor-killing effect. In summary, this material designed to capture CTCs provides a substantial advancement for personalized PTT-triggered immunotherapy and has great clinical translational potential.

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Acknowledgements

This work was supported by the National Natural Science Fund for Distinguished Young Scholars (No. 82225025), the National Natural Science Foundation of China (Nos. 21877049 and 32171296), China Postdoctoral Science Foundation (No. 2021M690066), Guangdong Basic and Applied Basic Research Foundation (No. 2021A1515110300).

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Author notes

  1. Hongjie Huang and Binhua Zou contributed equally to this work.

Authors and Affiliations

  1. The Sixth Affiliated Hospital, Jinan University, Dongguan, 523566, China

    Hongjie Huang, Binhua Zou, Xiaoling Li & Tianfeng Chen

  2. Department of Chemistry, Institute of Food Safety and Nutrition, Jinan University, Guangzhou, 510632, China

    Hongjie Huang, Binhua Zou, Shanlin Zhu, Xingchen Zhang, Jiale Huang & Xiaoling Li

  3. Department of Rehabilitation Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China

    Binhua Zou

  4. Pulmonary and Critical Care Medicine, Guangzhou Institute of Respiratory Health, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, State Key Laboratory of Respiratory Diseases, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China

    Jinlin Wang

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  1. Hongjie Huang
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  3. Shanlin Zhu
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Correspondence to Jinlin Wang, Xiaoling Li or Tianfeng Chen.

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Huang, H., Zou, B., Zhu, S. et al. PD-L1-driven efficient enrichment and elimination of circulating cancer cells by magnetic MoSe2 nanosheet. Nano Res. 17, 4350–4358 (2024). https://doi.org/10.1007/s12274-023-6342-2

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  • DOI: https://doi.org/10.1007/s12274-023-6342-2

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