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Graphdiyne oxide substrate-enhanced peroxidase-mimicking performance of Ru nanoparticles with physiological pH preference

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Abstract

Modulating electronic structure of metal nanoparticles via metal–support interaction has attracted intense interest in the field of catalytic science. However, the roles of supporting substrates in regulating catalytic properties of nanozymes remain elusive. In this study, we find that the use of graphdiyne oxide (GDYO) as the substrate for self-terminating growth of Ru nanoparticles (Ru@GDYO) endows the peroxidase-like activity of Ru nanoparticles with intrinsic physiological pH preference and natural horseradish peroxidase (HRP) comparable performance. Ru nanoparticles electrolessly deposited onto GDYO possess a partially oxidized electronic structure owing to limited charge transfer between Ru and GDYO, contributing to the intrinsic physiological pH preference of the peroxidase-mimicking nanozyme. More importantly, the substrate GDYO plays an influential factor in enhancing catalytic activity, that is, the activity of Ru@GDYO is much higher than that of Ru nanoparticles deposited on other carbon substrates including graphene oxides and graphdiyne. To demonstrate the application of Ru@GDYO nanozyme in neutral solutions, we employ Ru@GDYO with nicotinamide adenine dinucleotide (NAD+)-dependent dehydrogenases in physiological conditions to realize a sustainable cascade reaction by means of forming continuous NAD+/dihydronicotiamide adenine dinucleotide (NADH) recycling. Our finding represents a promising perspective on designing high-performance peroxidase-mimicking nanozymes with broader applicability, raising fundamental understanding of structure–activity relationship, and investigating new applications of nanozymes in biological systems.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (Nos. 22134002 to L. M., 22125406, 22074149, and 21790053 to P. Y.), the Strategic Priority Research Program of Chinese Academy of Sciences (No. XDB30000000), and the National Basic Research Program of China (No. 2018YFA0703501).

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Authors and Affiliations

  1. Beijing National Laboratory for Molecular Science, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China

    Cong Xu, Wenjie Ma, Leihou Shao, Weiqi Li, Ping Yu & Lanqun Mao

  2. University of Chinese Academy of Sciences, Beijing, 100049, China

    Cong Xu, Wenjie Ma, Weiqi Li & Ping Yu

  3. State Key Laboratory of Marine Resource Utilization in South China Sea, School of Materials Science and Engineering, Hainan University, Haikou, 570228, China

    Haozhi Wang

  4. College of Chemistry, Beijing Normal University, Beijing, 100875, China

    Lanqun Mao

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  1. Cong Xu
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Correspondence to Ping Yu or Lanqun Mao.

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Graphdiyne oxide substrate-enhanced peroxidase-mimicking performance of Ru nanoparticles with physiological pH preference

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Xu, C., Ma, W., Wang, H. et al. Graphdiyne oxide substrate-enhanced peroxidase-mimicking performance of Ru nanoparticles with physiological pH preference. Nano Res. 17, 1123–1131 (2024). https://doi.org/10.1007/s12274-023-5931-4

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