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Coordination-driven self-assembly of metallo-nanodrugs for local inflammation alleviation

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Abstract

Developing dedicated nanomedicines to improve delivery efficacy of anti-inflammatory drugs is still a formidable challenge. In this study, we present an extremely simple yet efficient approach to obtain hybrid nanodrugs through metal-drug coordination-driven self-assembly for carrier-free drug delivery. The resulting metallo-nanodrugs exhibit well-defined morphology and high drug encapsulation capability, allowing for the combination of magnetic resonance imaging and anti-inflammatory therapy. In the case of osteoarthritis (OA), the metallo-nanodrugs remarkably alleviate synovial inflammation, preventing cartilage destruction and extracellular matrix loss. In addition, it led to significantly improved therapeutic efficacy compared with intra-articular administration of the same dose of free drugs in OA mouse model. This work provides a very simple approach for the development of anti-inflammatory nanoformulations by exploiting coordination-driven self-assembly.

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Acknowledgements

This work was financially funded by the Beijing Natural Science Foundation (No. JQ20005) and Guangxi Science and Technology Major Project (No. GuikeAA19254002).

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Author notes

  1. Lijuan Tang and Zhenghan Di contributed equally to this work.

Authors and Affiliations

  1. Guangxi Key Laboratory of Regenerative Medicine, Guangxi Engineering Center in Biomedical Material for Tissue and Organ Regeneration, Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development nd Application Co-Constructed by the Province and Ministry, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China

    Lijuan Tang, Feiying Yin & Li Zheng

  2. Pharmaceutical College, Guangxi Medical University, Nanning, 530021, China

    Lijuan Tang

  3. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing, 100190, China

    Lijuan Tang, Zhenghan Di, Jingfang Zhang & Lele Li

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  1. Lijuan Tang
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  2. Zhenghan Di
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  4. Feiying Yin
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Correspondence to Lele Li or Li Zheng.

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Tang, L., Di, Z., Zhang, J. et al. Coordination-driven self-assembly of metallo-nanodrugs for local inflammation alleviation. Nano Res. 16, 13259–13266 (2023). https://doi.org/10.1007/s12274-023-5721-z

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