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Tumor microenvironment-responsive modular integrated nanocomposites for magnetically targeted and photothermal enhanced catalytic therapy

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Abstract

Achieving efficient integration of cancer diagnosis and therapy is of great significance to human health, but the construction of a multifunctional intelligent therapy system still faces great challenges. In this study, we report an integrated multifunctional nanocomposite constructed by a simple modular assembly technology. The nanocomposites are composed of three different nanomaterials: Fe3O4, Au, and NaErF4:0.5%Tm@NaYF4 upconversion nanoparticles (UCNPs). In this design, Fe3O4 nanoparticles have nanozyme effect of peroxidase-like activity, which can react with H2O2 in the tumor microenvironment to generate hydroxyl radicals. Because of its magnetic properties, it can help the nanocomposites to aggregate under the induction of magnetic fields. Au nanoparticles exhibit nanozyme effect of glucose oxidase-like activity. It can catalyze the conversion of glucose to gluconic acid and H2O2. Ingeniously, the generated H2O2 provides a source of reactants for the reaction of the Fe3O4 nanozyme. In addition, the photothermal effect of Au nanoparticles under 808 nm irradiation further enhanced the nanozyme activity of Fe3O4 and Au nanoparticles. Besides, UCNPs can emit near-infrared (NIR)-II fluorescence under 808 nm irradiation, which can provide imaging-guided during cancer treatment. Then, the nanocomposites were further modified by poly(vinylpyrrolidone) (PVP) to obtain UCNPs/Au/Fe3O4-PVP with good biocompatibility and high-efficiency cancer treatment ability.

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Acknowledgements

This work was supported by the financial aid from the National Natural Science Foundation of China (Nos. 22020102003, 21834007, and 52103276), the National Key R&D Program of China (No. 2020YFA0712102), the Program of Science and Technology Development Plan of Jilin Province of China (No. 20220508076RC), the Natural Science Foundation of Guangdong Province of China (No. 2022A1515010947), and Guangzhou Basic and Applied Basic Research Foundation (No. 202201011343).

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  1. Yuan Liang and Yilin Liu contributed equally to this work.

Authors and Affiliations

  1. State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, 130022, China

    Yuan Liang, Pengpeng Lei & Hongjie Zhang

  2. School of Materials Science and Engineering, Sun Yat-sen University, Guangzhou, 510275, China

    Yilin Liu & Zhen Zhang

  3. School of Rare Earths, University of Science and Technology of China, Hefei, 230026, China

    Yuan Liang & Hongjie Zhang

  4. Ganjiang Innovation Academy, Chinese Academy of Sciences, Ganzhou, 341000, China

    Yuan Liang & Hongjie Zhang

  5. Department of Chemistry, Tsinghua University, Beijing, 100084, China

    Hongjie Zhang

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  1. Yuan Liang
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  2. Yilin Liu
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  3. Pengpeng Lei
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  4. Zhen Zhang
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Correspondence to Pengpeng Lei, Zhen Zhang or Hongjie Zhang.

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Tumor microenvironment-responsive modular integrated nanocomposites for magnetically targeted and photothermal enhanced catalytic therapy

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Liang, Y., Liu, Y., Lei, P. et al. Tumor microenvironment-responsive modular integrated nanocomposites for magnetically targeted and photothermal enhanced catalytic therapy. Nano Res. 16, 9826–9834 (2023). https://doi.org/10.1007/s12274-023-5706-y

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