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A hydrogel system containing molybdenum-based nanomaterials for wound healing

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Abstract

Wound delayed healing or non-healing has seriously affected patients’ quality of life and has been a significant economic burden for public health systems worldwide. Excess reactive oxygen species (ROS) play important roles for impeding the process of wound healing. Herein, we report a hydrogel system containing low-valence-state molybdenum nanomaterials (Mo hydrogel) for wound healing by scavenging the detrimental ROS. Both in vitro and in vivo results demonstrate that the synthesized Mo hydrogel can accelerate wound healing, promote angiogenesis, and stimulate the expression of growth factors. Since the molybdenum is an essential element for the survival of all organisms, such novel Mo-hydrogel has the great potential to be clinically translated for wound healing.

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Acknowledgements

We greatly acknowledge the financial support from the National Natural Science Foundation of China (Nos. 82102190 and 81773347), Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support (No. 20191805), and the Foundation of National Facility for Translational Medicine (Shanghai) (No. TMSK-2021-122).

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Author notes

  1. Yongzhou Lu, Chuanlong Jia, and Chengchen Gong contributed equally to this work.

Authors and Affiliations

  1. Department of Dermatology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200092, China

    Yongzhou Lu, Chuanlong Jia, Chengchen Gong, Qin Xiao & Nan Xu

  2. Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China

    Han Wang & Dalong Ni

  3. Department of Orthopaedics, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Jiao Tong University, Shanghai, 200233, China

    Jinxiao Guo

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  1. Yongzhou Lu
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  2. Chuanlong Jia
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  3. Chengchen Gong
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  4. Han Wang
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  5. Qin Xiao
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  6. Jinxiao Guo
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  7. Dalong Ni
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  8. Nan Xu
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Correspondence to Jinxiao Guo, Dalong Ni or Nan Xu.

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Lu, Y., Jia, C., Gong, C. et al. A hydrogel system containing molybdenum-based nanomaterials for wound healing. Nano Res. 16, 5368–5375 (2023). https://doi.org/10.1007/s12274-022-5255-9

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  • DOI: https://doi.org/10.1007/s12274-022-5255-9

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