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Engineering CeO2/CuO heterostructure anchored on upconversion nanoparticles with boosting ROS generation-primed apoptosis-ferroptosis for cancer dynamic therapy

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Abstract

Highly toxic reactive oxygen species (ROS) induced apoptosis and ferroptosis have been considered as significant cell death pathways for cancer therapy. However, insufficient amount of intracellular ROS extremely restricts the therapeutic effect. Toward this, we report a rationally designed nanocomposite (mUCC) with enhanced ROS generation ability, inducing the combination of apoptosis and ferroptosis through synergistic photodynamic therapy (PDT) and chemodynamic therapy (CDT). Under 808 nm near-infrared (NIR) light irradiation, photocatalytic reaction is triggered starting from the separation of electron-hole pairs on the surface of heterojunction (CeO2/CuO), realizing improved ROS production. Simultaneously, mUCC served as Fenton-like agent exhibits considerable ability to generate highly toxic ·OH under tumor microenvironment (TME). The boosted accumulation of ROS disrupts the redox balance within tumor cells and results in the integration of apoptosis and ferroptosis. In addition, mUCC shows satisfactory tumor targeting property benefiting from the cancer cell membrane functionalization under the guidance of magnetic resonance imaging (MRI) and NIR fluorescence imaging. The intelligent mUCC with good biocompatibility and excellent antitumor response achieves efficient tumor elimination under synergistic PDT and CDT. This work offers an elective approach for further development of ROS-based therapeutic nanoplatform in cancer therapy.

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Acknowledgements

This work was supported by the financial aid from the National Key Research and Development Program of China (No. 2021YFF0701800), the National Natural Science Foundation of China (Nos. 21871248, 21834007, and 22020102003), K. C. Wong Education Foundation (No. GJTD-2018-09), the Youth Innovation Promotion Association of Chinese Academy of Sciences (No. Y201947), and Jilin Province Science and Technology Development Plan Project (No. 20220101063JC).

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Authors and Affiliations

  1. State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China

    Xuan Gao, Jing Feng, Kehong Lv, Yifei Zhou, Ruohao Zhang, Shuyan Song & Hongjie Zhang

  2. School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, 230026, China

    Xuan Gao, Jing Feng, Kehong Lv, Yifei Zhou, Ruohao Zhang, Shuyan Song & Hongjie Zhang

  3. Department of Chemistry, Tsinghua University, Beijing, 100084, China

    Hongjie Zhang

  4. Gastric and Intestinal Department, General Surgery Center, First Hospital of Jilin University, Changchun, 130021, China

    Daguang Wang

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  1. Xuan Gao
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Correspondence to Jing Feng, Hongjie Zhang or Daguang Wang.

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Engineering CeO2/CuO heterostructure anchored on upconversion nanoparticles with boosting ROS generation-primed apoptosis-ferroptosis for cancer dynamic therapy

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Gao, X., Feng, J., Lv, K. et al. Engineering CeO2/CuO heterostructure anchored on upconversion nanoparticles with boosting ROS generation-primed apoptosis-ferroptosis for cancer dynamic therapy. Nano Res. 16, 5322–5334 (2023). https://doi.org/10.1007/s12274-022-5223-4

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