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Aza-BODIPY-based phototheranostic nanoagent for tissue oxygen auto-adaptive photodynamic/photothermal complementary therapy

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Abstract

Tumor oxygen spatial heterogeneity is a critical challenge for the photodynamic inhibition of solid tumors. Development of an intelligent nanoagent to initiate optimal therapeutics according to the localized oxygen levels is an effective settlement. Herein, we report an activatable nanoagent (BDP-Oxide nanoparticles (NPs)) to enable the oxygen auto-adaptive photodynamic/photothermal complementary treatment. Upon the nanoagent accumulated in the tumor region, the low extracellular pH could trigger the disassociation of the nanoagent to release the phototheranostic agent, BDP-Oxide, which will subsequently afford the fluorescence imaging-guided photodynamic oxidation after it gets into the outer oxygen-rich tumors. Along with the penetration deepening in the solid tumor, furthermore, BDP-Oxide could be reduced into BDP by the cytochrome P450 (CYP450) enzymes activated in the low oxygen tension regions of inner hypoxic tumors, which will switch on the photothermal and photoacoustic effects. Overall, the BDP-Oxide NPs-enabled photodynamic/photothermal complementary therapy significantly suppressed the solid tumor growth (inhibition rate of 94.8%). This work proposes an intelligent platform to address the oxygen partial pressure for the optimization of cancer phototherapeutics.

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Acknowledgements

This research was supported by the National Natural Science Foundation of China (No. 21771065), Guangdong Special Support Program (No. 2017TQ04R138), Science and Technology Program of Guangzhou (No. 2019050001), Natural Science Foundation of Guangdong (No. 2019A1515012021), Pearl River Nova Program of Guangzhou (No. 201806010189), and the Major Program of Ningbo Science and Technology Innovation 2025 (No. 2020Z093).

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Authors and Affiliations

  1. MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, South China Normal University, Guangzhou, 510631, China

    Meijiao Zhao, Qin Zeng, Xipeng Li, Da Xing & Tao Zhang

  2. Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, 510631, China

    Meijiao Zhao, Qin Zeng, Xipeng Li, Da Xing & Tao Zhang

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  1. Meijiao Zhao
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  2. Qin Zeng
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  4. Da Xing
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Correspondence to Da Xing or Tao Zhang.

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Aza-BODIPY-based phototheranostic nanoagent for tissue oxygen auto-adaptive photodynamic/photothermal complementary therapy

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Zhao, M., Zeng, Q., Li, X. et al. Aza-BODIPY-based phototheranostic nanoagent for tissue oxygen auto-adaptive photodynamic/photothermal complementary therapy. Nano Res. 15, 716–727 (2022). https://doi.org/10.1007/s12274-021-3552-3

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