Abstract
A novel series of dihydropyranoaurone derivatives were synthesized and evaluated as potential anti-inflammatory agents. Late-stage derivatization by versatile piperazine-catalyzed aldol reaction between dihydropyanobenzofuran intermediate 2 and diverse aldehydes readily afforded the novel dihydropyranoaurone analogs. Evaluation of the synthesized dihydropyranoaurone derivatives and related compounds regarding their inhibiting inducible nitric oxide synthase and nitrite production of lipopolysaccaride-stimulated RAW 264.7 cells provided insight into the structure–activity relationship of aurone derivatives.
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Wang, Z., Bae, E.J. & Han, Y.T. Synthesis and anti-inflammatory activities of novel dihydropyranoaurone derivatives. Arch. Pharm. Res. 40, 695–703 (2017). https://doi.org/10.1007/s12272-017-0910-5
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DOI: https://doi.org/10.1007/s12272-017-0910-5