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Chronic Stress Impairs Collateral Blood Flow Recovery in Aged Mice

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Abstract

Chronic stress is associated with increased risk of cardiovascular diseases. Aging is also associated with vascular dysfunction. We hypothesize that chronic stress accelerates collateral dysfunction in old mice. Mice were subjected to either chronic social defeat (CSD) or chronic cold stress (CCS). The CSD mice were housed in a box inside an aggressor’s cage and exposed to the aggressor. The CCS group was placed in iced water. After chronic stress, mice underwent femoral artery ligation (FAL) and flow recovery was measured. For the CSD group, appearance and use scores of the foot and a behavioral test were performed. CSD impaired collateral flow recovery after FAL. Further, stressed mice had greater ischemic damage, impaired foot function, and altered behavior. The CCS mice also showed impaired collateral flow recovery. Chronic stress causes hind limb collateral dysfunction in old mice, a conclusion reinforced by the fact that two types of stress produced similar changes.

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Abbreviations

CSD:

Chronic social defeat stress

Ctrl CSD:

Control chronic social defeat stress

CCS:

Chronic cold stress

Ctrl CCS:

Control chronic cold stress

AGG:

Aggressor

FAL:

Femoral artery ligation

LDPI:

Laser Doppler perfusion imaging

PTSD:

Posttraumatic stress disorder

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Acknowledgments

This project has been funded in part with Federal Funds (Grant No. RR31975) from the National Center for Research Resources (NCRR) and National Institutes of Health (NIH) through the Clinical and Translational Science Awards Program (CTSA), a trademark of the DHHS, part of the Roadmap Initiative, “Re-Engineering the Clinical Research Enterprise.” This was funded also by MedStar Health Research Institute (MHRI), Washington, DC.

Conflict of interest

No conflicts of interest, financial, or otherwise are declared by the authors. The views, opinions, and/or findings contained in this report are those of the authors and should not be construed as official Department of the Army position, policy, or decision, unless so designated by other official documentation. Citations of commercial organizations or trade names in this report do not constitute an official Department of the Army endorsement or approval of the products or services of these organizations.

Human Subjects/Informed Consent Statement

No human studies were carried out by the authors for this article.

Animal Studies

Research was conducted in compliance with the Animal Welfare Act and other Federal statutes and regulations relating to animals and experiments involving animals and adheres to principles stated in the Guide for the Care and Use of Laboratory Animals (NRC 2011) in facilities that are fully accredited by the Association for the Assessment and Accreditation of Laboratory Animal Care, International.

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Authors and Affiliations

  1. MedStar Cardiovascular Research Network, MedStar Heart Institute, Washington Hospital Center, 108 Irving Street, NW Room 214, Washington, DC, 20010, USA

    Roberta M. Lassance-Soares, Subeena Sood, Sunny Jhamnani, Nima Aghili, Hajra Nashin, Stephen E. Epstein & Mary Susan Burnett

  2. Integrative Systems Biology, US Army Center for Environmental Health Research, Fort Detrick, Frederick, MD, 21702-5010, USA

    Nabarun Chakraborty, Rasha Hammamieh & Marti Jett

Authors
  1. Roberta M. Lassance-Soares
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  2. Subeena Sood
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  3. Nabarun Chakraborty
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  4. Sunny Jhamnani
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  5. Nima Aghili
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  6. Hajra Nashin
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  7. Rasha Hammamieh
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  8. Marti Jett
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  9. Stephen E. Epstein
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  10. Mary Susan Burnett
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Corresponding author

Correspondence to Mary Susan Burnett.

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Editor-in-Chief Jennifer L. Hall oversaw the review of this article

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Lassance-Soares, R.M., Sood, S., Chakraborty, N. et al. Chronic Stress Impairs Collateral Blood Flow Recovery in Aged Mice. J. of Cardiovasc. Trans. Res. 7, 749–755 (2014). https://doi.org/10.1007/s12265-014-9592-2

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  • DOI: https://doi.org/10.1007/s12265-014-9592-2

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