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Pericyte Plasticity in the Brain

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Abstract

Cerebral pericytes are perivascular cells that stabilize blood vessels. Little is known about the plasticity of pericytes in the adult brain in vivo. Recently, using state-of-the-art technologies, including two-photon microscopy in combination with sophisticated Cre/loxP in vivo tracing techniques, a novel role of pericytes was revealed in vascular remodeling in the adult brain. Strikingly, after pericyte ablation, neighboring pericytes expand their processes and prevent vascular dilatation. This new knowledge provides insights into pericyte plasticity in the adult brain.

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Acknowledgements

A. Birbrair was supported by Grants from Instituto Serrapilheira/Serra-1708-15285, Pró-reitoria de Pesquisa/Universidade Federal de Minas Gerais (PRPq/UFMG) (Edital 05/2016), the National Institute of Science and Technology in Theranostics and Nanobiotechnology (CNPq/CAPES/FAPEMIG, Process No. 465669/2014-0), FAPEMIG [Rede Mineira de Engenharia de Tecidos e Terapia Celular (REMETTEC, RED-00570-16)], and FAPEMIG [Rede De Pesquisa Em Doenças Infecciosas Humanas E Animais Do Estado De Minas Gerais (RED-00313-16)]. Akiva Mintz was supported by the National Institute of Health (1R01CA179072-01A1) and an American Cancer Society Mentored Research Scholar Grant (124443-MRSG-13-121-01-CDD).

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Authors and Affiliations

  1. Departamento de Patologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil

    Gabryella S. P. Santos & Alexander Birbrair

  2. Department of Mental Health, Federal University of Minas Gerais, Belo Horizonte, MG, 30130-100, Brazil

    Luiz A. V. Magno & Marco A. Romano-Silva

  3. Department of Radiology, Columbia University Medical Center, New York, NY, 10032, USA

    Akiva Mintz & Alexander Birbrair

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  1. Gabryella S. P. Santos
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Correspondence to Alexander Birbrair.

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Santos, G.S.P., Magno, L.A.V., Romano-Silva, M.A. et al. Pericyte Plasticity in the Brain. Neurosci. Bull. 35, 551–560 (2019). https://doi.org/10.1007/s12264-018-0296-5

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