Abstract
All different types of metabolism of tumors are dependent on the flow of water molecules through the biological membrane, where fluid transfer interceded by aquaporins (AQPs) are the basis means for water entrance into the cells or outside them. Aquaporins play other roles including cellular migration, cellular expansion and cellular adhesion facilitation. Therefore, regulators of AQPs may be useful anticancer agents. Medline, Scopus, Embase, and Web of Sciences were searched. From among the papers found, 106 were related to the subject. All of the examined cancers in relation to AQP1 included adenoid cystic carcinoma, bladder, breast, cervical, colon, colorectal, hepatocellular, lung, ovarian, plural mesothelioma, prostate, renal cell carcinoma and squamous cell carcinoma. All of the studied cancers in relation with AQP3 included gastric, breast, prostate, lung, pancreas, skin, bladder, squamous cell carcinoma, cervical, adenoid cystic carcinoma, colon, colorectal, ovarian, and hepatocellular cancers and with regard to AQP5 were lung, squamous cell carcinoma, ovarian, adenoid cystic carcinoma, breast, colon, colorectal, hepatic, pancreas, gallbladder, prostate, and gastric cancers. Over or under-expression of AQP1, 3 and is exist in the mentioned cancers across different studies. Over-expression of AQP1, AQP3 and AQP5 is clearly associated with carcinogenesis, metastasis, reduced survival rate, lymph node metastasis, poorer prognosis, and cellular migration. Also, cancer treatments in relation to these markers suggest AQP reduction during the treatment.
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References
Wang L, Zhang Y, Wu X, Yu G (2016) Aquaporins: new targets for cancer therapy. Technol Cancer Res Treat 15(6):821–828
Verkman AS, Anderson MO, Papadopoulos MC (2014) Aquaporins: important but elusive drug targets. Nat Rev Drug Discov 13(4):259–277
Papadopoulos MC, Saadoun S (2015) Key roles of aquaporins in tumor biology. Biochim Biophys Acta Biomembr 1848(10):2576–2583
Direito I, Madeira A, Brito MA, Soveral G (2016) Aquaporin-5: from structure to function and dysfunction in cancer. Cell Mol Life Sci 73(8):1623–1640
Takata K, Matsuzaki T, Tajika Y (2004) Aquaporins: water channel proteins of the cell membrane. Prog Histochem Cytochem 39(1):1–83
Tomita Y, Dorward H, Yool A, Smith E, Townsend A, Price T, Hardingham J (2017) Role of aquaporin 1 signalling in cancer development and progression. Int J Mol Sci 18(2):299
Niu D, Kondo T, Nakazawa T, Yamane T, Mochizuki K, Kawasaki T, Matsuzaki T, Takata K, Katoh R (2012) Expression of aquaporin3 in human neoplastic tissues. Histopathology. 61(4):543–551
Jensen HH, Login FH, Koffman JS, Kwon T-H, Nejsum LN (2016) The role of aquaporin-5 in cancer cell migration: a potential active participant. Int J Biochem Cell Biol 79:271–276
Tan M, Shao C, Bishop JA, Feng Z, Trock BJ, Westra WH, Ha PK (2014) Aquaporin-1 promoter hypermethylation is associated with improved prognosis in salivary gland adenoid cystic carcinoma. Otolaryngol Head Neck Surg 150(5):801–807
Zhang X, Chen Y, Dong L, Shi B (2018) Effect of selective inhibition of aquaporin 1 on chemotherapy sensitivity of J82 human bladder cancer cells. Oncol Lett 15(3):3864–3869
Zou W, Yang Z, Li D, Liu Z, Zou Q, Yuan Y (2019) AQP1 and AQP3 expression are associated with severe symptoms and poor-prognosis of the pancreatic ductal adenocarcinoma. Appl Immunohistochem Mol Morphol 27(1):40–47
Luo L, Yang R, Zhao S, Chen Y, Hong S, Wang K, Wang T, Cheng J, Zhang T, Chen D (2018) Decreased miR-320 expression is associated with breast cancer progression, cell migration, and invasiveness via targeting aquaporin 1. Acta Biochim Biophys Sin 50(5):473–480
Qin F, Zhang H, Shao Y, Liu X, Yang L, Huang Y et al (2016) Expression of aquaporin1, a water channel protein, in cytoplasm is negatively correlated with prognosis of breast cancer patients. Oncotarget. 7(7):8143
Yin T, Yu S, Xiao L, Zhang J, Liu C, Lu Y et al (2008) Correlation between the expression of aquaporin 1 and hypoxia-inducible factor 1 in breast cancer tissues. J Huazhong Univ Sci Technolog Med Sci 28(3):346
Shi Y-H, Chen R, Talafu T, Nijiati R, Lalai S (2012) Significance and expression of aquaporin 1, 3, 8 in cervical carcinoma in Xinjiang Uygur women of China. Asian Pac J Cancer Prev 13(5):1971–1975
Dorward HS, Du A, Bruhn MA, Wrin J, Pei JV, Evdokiou A et al (2016) Pharmacological blockade of aquaporin-1 water channel by AqB013 restricts migration and invasiveness of colon cancer cells and prevents endothelial tube formation in vitro. J Exp Clin Cancer Res 35(1):36
Jiang Y (2009) Aquaporin-1 activity of plasma membrane affects HT20 colon cancer cell migration. IUBMB Life 61(10):1001–1009
Kang BW, Kim JG, Lee SJ, Chae YS, Jeong JY, Yoon GS, Park SY, Kim HJ, Park JS, Choi GS, Jeong JY (2015) Expression of aquaporin-1, aquaporin-3, and aquaporin-5 correlates with nodal metastasis in colon cancer. Oncology. 88(6):369–376
Yoshida T, Hojo S, Sekine S, Sawada S, Okumura T, Nagata T et al (2013) Expression of aquaporin-1 is a poor prognostic factor for stage II and III colon cancer. Mol Clin Oncol 1(6):953–958
Imaizumi H, Ishibashi K, Takenoshita S, Ishida H (2018) Aquaporin 1 expression is associated with response to adjuvant chemotherapy in stage II and III colorectal cancer. Oncol Lett 15(5):6450–6456
Luo LM, Xia H, Shi R, Zeng J, Liu XR, Wei M (2017) The association between aquaporin-1 expression, microvessel density and the clinicopathological features of hepatocellular carcinoma. Oncol Lett 14(6):7077–7084
Bellezza G, Vannucci J, Bianconi F, Metro G, Del Sordo R, Andolfi M et al (2017) Prognostic implication of aquaporin 1 overexpression in resected lung adenocarcinoma. Interact Cardiovasc Thorac Surg 25(6):856–861
Hoque MO, Soria J-C, Woo J, Lee T, Lee J, Jang SJ, Upadhyay S, Trink B, Monitto C, Desmaze C, Mao L, Sidransky D, Moon C (2006) Aquaporin 1 is overexpressed in lung cancer and stimulates NIH-3T3 cell proliferation and anchorage-independent growth. Am J Pathol 168(4):1345–1353
Liu Y, Zhu W (2015) Effects of cetuximab combined with afatinib on the expression of KDR and AQP1 in lung cancer. Genet Mol Res 14(4):16652–16661
Takal MK, Baykal C, Başer E, Kaya MD, Dursun P, Özen Ö et al (2013) Does Aquaporin-1 expression have clinical significance in serous epithelial ovarian cancer? J Turk Ger Gynecol Assoc 14(3):130–135
Sato K, Miyamoto M, Takano M, Furuya K, Tsuda H (2018) Different prognostic implications of Aquaporin-1 and Aquaporin-5 expression among different histological types of ovarian carcinoma. Pathol Oncol Res:1–9
Wang Y, Fan Y, Zheng C, Zhang X (2017) Knockdown of AQP1 inhibits growth and invasion of human ovarian cancer cells. Mol Med Rep 16(4):5499–5504
Angelico G, Caltabiano R, Loreto C, Ieni A, Tuccari G, Ledda C, Rapisarda V (2018) Immunohistochemical expression of Aquaporin-1 in Fluoro-Edenite-induced malignant mesothelioma: a preliminary report. Int J Mol Sci 19(3):685
Jagirdar RM, Apostolidou E, Molyvdas PA, Gourgoulianis KI, Hatzoglou C, Zarogiannis SG (2016) Influence of AQP1 on cell adhesion, migration, and tumor sphere formation in malignant pleural mesothelioma is substratum-and histological-type dependent. Am J Phys Lung Cell Mol Phys 310(6):L489–LL95
Kao SCH, Armstrong N, Condon B, Griggs K, McCaughan B, Maltby S, Wilson A, Henderson DW, Klebe S (2012) Aquaporin 1 is an independent prognostic factor in pleural malignant mesothelioma. Cancer. 118(11):2952–2961
Pan X-Y, Guo H, Han J, Hao F, An Y, Xu Y, Xiaokaiti Y, Pan Y, Li XJ (2012) Ginsenoside Rg3 attenuates cell migration via inhibition of aquaporin 1 expression in PC-3M prostate cancer cells. Eur J Pharmacol 683(1–3):27–34
Tie L, Lu N, Pan X-Y, Pan Y, An Y, Gao J-W, Lin YH, Yu HM, Li XJ (2012) Hypoxia-induced up-regulation of aquaporin-1 protein in prostate cancer cells in a p38-dependent manner. Cell Physiol Biochem 29(1–2):269–280
Huang Y, Murakami T, Sano F, Kondo K, Nakaigawa N, Kishida T, Kubota Y, Nagashima Y, Yao M (2009) Expression of aquaporin 1 in primary renal tumors: a prognostic indicator for clear-cell renal cell carcinoma. Eur Urol 56(4):690–699
Morrissey JJ, Kharasch ED (2013) The specificity of urinary aquaporin 1 and perilipin 2 to screen for renal cell carcinoma. J Urol 189(5):1913–1920
Morrissey JJ, Mobley J, Song J, Vetter J, Luo J, Bhayani S et al (2014) Urinary concentrations of aquaporin-1 and perilipin-2 in patients with renal cell carcinoma correlate with tumor size and stage but not grade. Urology 83(1):256. e9–256. e14
Morrissey JJ, Mobley J, Figenshau RS, Vetter J, Bhayani S, Kharasch ED, eds (2015) Urine aquaporin 1 and perilipin 2 differentiate renal carcinomas from other imaged renal masses and bladder and prostate cancer. Mayo Clinic Proceedings. Elsevier
Morrissey JJ, Mellnick VM, Luo J, Siegel MJ, Figenshau RS, Bhayani S, Kharasch ED (2015) Evaluation of urine aquaporin-1 and perilipin-2 concentrations as biomarkers to screen for renal cell carcinoma: a prospective cohort study. JAMA Oncol 1(2):204–212
Sreedharan S, Petros JA, Master VA, Ogan K, Pattaras JG, Roberts DL, Lian F, Arnold RS (2014) Aquaporin-1 protein levels elevated in fresh urine of renal cell carcinoma patients: potential use for screening and classification of incidental renal lesions. Dis Markers 2014:1–6
Ticozzi-Valerio D, Raimondo F, Pitto M, Rocco F, Bosari S, Perego R, Sarto C, di Fonzo A, Bosso N, Mocarelli P, Galli-Kienle M, Magni F (2007) Differential expression of AQP1 in microdomain-enriched membranes of renal cell carcinoma. Proteomics Clin Appl 1(6):588–597
Lehnerdt G, Bachmann H, Adamzik M, Panic A, Köksal E, Weller P et al (2015) AQP1, AQP5, Bcl-2 and p16 in pharyngeal squamous cell carcinoma. J Laryngol Otol 129(6):580–586
Yamazato Y, Shiozaki A, Ichikawa D, Kosuga T, Shoda K, Arita T et al (2018) Aquaporin 1 suppresses apoptosis and affects prognosis in esophageal squamous cell carcinoma. Oncotarget. 9(52):29957
Imrédi E, Tóth B, Doma V, Barbai T, Rásó E, Kenessey I, Tímár J (2016) Aquaporin 1 protein expression is associated with BRAF V600 mutation and adverse prognosis in cutaneous melanoma. Melanoma Res 26(3):254–260
Imrédi E, Liszkay G, Kenessey I, Plotár V, Gödény M, Tóth B et al (2018) Aquaporin-1 protein expression of the primary tumor may predict cerebral progression of cutaneous melanoma. Pathol Oncol Res:1–6
Zhou Y, Wang Y, Wen J, Zhao H, Dong X, Zhang Z et al (2016) Aquaporin 3 promotes the stem-like properties of gastric cancer cells via Wnt/GSK-3β/β-catenin pathway. Oncotarget. 7(13):16529
Chen J, Wang T, Zhou Y-C, Gao F, Zhang Z-H, Xu H, Wang SL, Shen LZ (2014) Aquaporin 3 promotes epithelial-mesenchymal transition in gastric cancer. J Exp Clin Cancer Res 33(1):38
Zhao H, Wen J, Dong X, He R, Gao C, Zhang W et al (2017) Identification of AQP3 and CD24 as biomarkers for carcinogenesis of gastric intestinal metaplasia. Oncotarget. 8(38):63382
Zhao H, Yang X, Zhou Y, Zhang W, Wang Y, Wen J et al (2015) Potential role of aquaporin 3 in gastric intestinal metaplasia. Oncotarget. 6(36):38926
Wang J, Gui Z, Deng L, Sun M, Guo R, Zhang W, Shen L (2012) C-met upregulates aquaporin 3 expression in human gastric carcinoma cells via the ERK signalling pathway. Cancer Lett 319(1):109–117
Xu H, Xu Y, Zhang W, Shen L, Yang L, Xu Z (2011) Aquaporin-3 positively regulates matrix metalloproteinases via PI3K/AKT signal pathway in human gastric carcinoma SGC7901 cells. J Exp Clin Cancer Res 30(1):86
Wang G, Gao F, Zhang W, Chen J, Wang T, Zhang G, Shen L (2012) Involvement of aquaporin 3 in helicobacter pylori-related gastric diseases. PLoS One 7(11):e49104
Li Z, Li B, Zhang L, Chen L, Sun G, Zhang Q, Wang J, Zhi X, Wang L, Xu Z, Xu H (2016) The proliferation impairment induced by AQP3 deficiency is the result of glycerol uptake and metabolism inhibition in gastric cancer cells. Tumor Biol 37(7):9169–9179
Jiang B, Li Z, Zhang W, Wang H, Zhi X, Feng J, Chen Z, Zhu Y, Yang L, Xu H, Xu Z (2014) miR-874 inhibits cell proliferation, migration and invasion through targeting aquaporin-3 in gastric cancer. J Gastroenterol 49(6):1011–1025
Zhou Y, Wang Y, Wang S, Shen L (2015) Hyperglycemia promotes human gastric carcinoma progression via aquaporin 3. Dig Dis Sci 60(8):2338–2345
Kang S, Chae YS, Lee SJ, Kang BW, Kim JG, Kim WW et al (2015) Aquaporin 3 expression predicts survival in patients with HER2-positive early breast cancer. Anticancer Res 35(5):2775–2782
Cao X-C, Zhang W-R, Cao W-F, Liu B-W, Zhang F, Zhao H-M, Meng R, Zhang L, Niu RF, Hao XS, Zhang B (2013) Aquaporin3 is required for FGF-2-induced migration of human breast cancers. PLoS One 8(2):e56735
Huang Y-T, Zhou J, Shi S, Xu H-Y, Qu F, Zhang D, Chen YD, Yang J, Huang HF, Sheng JZ (2015) Identification of estrogen response element in aquaporin-3 gene that mediates estrogen-induced cell migration and invasion in estrogen receptor-positive breast cancer. Sci Rep 5:12484
Satooka H, Hara-Chikuma M (2016) Aquaporin-3 controls breast cancer cell migration by regulating hydrogen peroxide transport and its downstream cell signaling. Molecular and cellular biology. MCB. 00971–15
Arif M, Kitchen P, Conner MT, Hill EJ, Nagel D, Bill RM et al (2018) Downregulation of aquaporin 3 inhibits cellular proliferation, migration and invasion in the MDA-MB-231 breast cancer cell line. Oncol Lett 16(1):713–720
Hwang I, Jung S-I, Hwang E-C, Song SH, Lee H-S, Kim S-O, Kang TW, Kwon D, Park K (2012) Expression and localization of aquaporins in benign prostate hyperplasia and prostate cancer. Chonnam Med J 48(3):174–178
Ismail M, Bokaee S, Davies J, Harrington K, Pandha H (2009) Inhibition of the aquaporin 3 water channel increases the sensitivity of prostate cancer cells to cryotherapy. Br J Cancer 100(12):1889–1895
Chen J, Wang Z, Xu D, Liu Y, Gao Y (2015) Aquaporin 3 promotes prostate cancer cell motility and invasion via extracellular signal-regulated kinase 1/2-mediated matrix metalloproteinase-3 secretion. Mol Med Rep 11(4):2882–2888
Wang J, Tanji N, Kikugawa T, Shudou M, Song X, Yokoyama M (2007) Expression of aquaporin 3 in the human prostate. Int J Urol 14(12):1088–1092
Xiong G, Chen X, Zhang Q, Fang Y, Chen W, Li C, Zhang J (2017) RNA interference influenced the proliferation and invasion of XWLC-05 lung cancer cells through inhibiting aquaporin 3. Biochem Biophys Res Commun 485(3):627–634
Hou S-Y, Li Y-P, Wang J-H, Yang S-L, Wang Y, Wang Y, Kuang Y (2016) Aquaporin-3 inhibition reduces the growth of NSCLC cells induced by hypoxia. Cell Physiol Biochem 38(1):129–140
Direito I, Paulino J, Vigia E, Brito MA, Soveral G (2017) Differential expression of aquaporin-3 and aquaporin-5 in pancreatic ductal adenocarcinoma. J Surg Oncol 115(8):980–996
Huang X, Huang L, Shao M (2017) Aquaporin 3 facilitates tumor growth in pancreatic cancer by modulating mTOR signaling. Biochem Biophys Res Commun 486(4):1097–1102
Liu W, Wang K, Gong K, Li X, Luo K (2012) Epidermal growth factor enhances MPC-83 pancreatic cancer cell migration through the upregulation of aquaporin 3. Mol Med Rep 6(3):607–610
Ramadan WM, Gheida SF, El-Ashmawy AA, Shareef MM (2017) Aquaporin-3 expression in common hyperproliferative skin disorders: an immunohistochemical study. J Egypt Women Dermatol Soc 14(2):128–136
Seleit I, Bakry OA, Sharaky DA, Ragheb E (2015) Evaluation of aquaporin-3 role in nonmelanoma skin cancer: an immunohistochemical study. Ultrastruct Pathol 39(5):306–317
Otto W, Rubenwolf PC, Burger M, Fritsche H-M, Rößler W, May M, Hartmann A, Hofstädter F, Wieland WF, Denzinger S (2012) Loss of aquaporin 3 protein expression constitutes an independent prognostic factor for progression-free survival: an immunohistochemical study on stage pT1 urothelial bladder cancer. BMC Cancer 12(1):459
Rubenwolf P, Thomas C, Denzinger S, Hartmann A, Burger M, Georgopoulos NT, Otto W (2015) Loss of AQP3 protein expression is associated with worse progression-free and cancer-specific survival in patients with muscle-invasive bladder cancer. World J Urol 33(12):1959–1964
Ishimoto S, Wada K, Usami Y, Tanaka N, Aikawa T, Okura M et al (2012) Differential expression of aquaporin 5 and aquaporin 3 in squamous cell carcinoma and adenoid cystic carcinoma. Int J Oncol 41(1):67–75
Søland TM, Ulekleiv CH, Galtung HK (2015) Hypoxia influence aquaporin 3 (AQP3) and migration in oral squamous cell carcinoma (OSCC). Oral Surg Oral Med Oral Pathol Oral Radiol 119(3):e181
Kusayama M, Wada K, Nagata M, Ishimoto S, Takahashi H, Yoneda M, Nakajima A, Okura M, Kogo M, Kamisaki Y (2011) Critical role of aquaporin 3 on growth of human esophageal and oral squamous cell carcinoma. Cancer Sci 102(6):1128–1136
Chen R, Shi Y, Amiduo R, Tuokan T, Suzuk L (2014) Expression and prognostic value of aquaporin 1, 3 in cervical carcinoma in women of Uygur ethnicity from Xinjiang, China. PloS One 9(6):e98576
Li A, Lu D, Zhang Y, Li J, Fang Y, Li F et al (2013) Critical role of aquaporin-3 in epidermal growth factor-induced migration of colorectal carcinoma cells and its clinical significance. Oncol Rep 29(2):535–540
Xuejun C, Weimin C, Xiaoyan D, Wei Z, Qiong Z, Jianhua Y (2014) Effects of aquaporins on chemosensitivity to cisplatin in ovarian cancer cells. Arch Gynecol Obstet 290(3):525–532
Ji C, Cao C, Lu S, Kivlin R, Amaral A, Kouttab N, Yang H, Chu W, Bi Z, di W, Wan Y (2008) Curcumin attenuates EGF-induced AQP3 up-regulation and cell migration in human ovarian cancer cells. Cancer Chemother Pharmacol 62(5):857–865
Peng R, Zhang Y, Zhao G, Li J, Shen X, Wang J, Sun JY (2016) Differential regulation of the expression of aquaporins 3 and 9 by Auphen and dbcAMP in the SMMC-7721 hepatocellular carcinoma cell line. Biotech Histochem 91(5):333–341
Chen G, Shi Y, Liu M, Sun J (2018) circHIPK3 regulates cell proliferation and migration by sponging miR-124 and regulating AQP3 expression in hepatocellular carcinoma. Cell Death Dis 9(2):175
Machida Y, Ueda Y, Shimasaki M, Sato K, Sagawa M, Katsuda S, Sakuma T (2011) Relationship of aquaporin 1, 3, and 5 expression in lung cancer cells to cellular differentiation, invasive growth, and metastasis potential. Hum Pathol 42(5):669–678
Jo YM, Park TI, Lee HY, Jeong JY, Lee WK (2016) Prognostic significance of aquaporin 5 expression in non-small cell lung cancer. J Pathol Transl Med 50(2):122–128
Song T, Yang H, Ho JCM, Tang SCW, Sze SCW, Lao L et al (2015) Expression of aquaporin 5 in primary carcinoma and lymph node metastatic carcinoma of non-small cell lung cancer. Oncol Lett 9(6):2799–2804
Chae YK, Woo J, Kim M-J, Kang SK, Kim MS, Lee J, Lee SK, Gong G, Kim YH, Soria JC, Jang SJ, Sidransky D, Moon C (2008) Expression of aquaporin 5 (AQP5) promotes tumor invasion in human non small cell lung cancer. PLoS One 3(5):e2162
Liu S, Zhang S, Jiang H, Yang Y, Jiang Y (2013) Co-expression of AQP3 and AQP5 in esophageal squamous cell carcinoma correlates with aggressive tumor progression and poor prognosis. Med Oncol 30(3):636
Shimizu H, Shiozaki A, Ichikawa D, Fujiwara H, Konishi H, Ishii H, Komatsu S, Kubota T, Okamoto K, Kishimoto M, Otsuji E (2014) The expression and role of aquaporin 5 in esophageal squamous cell carcinoma. J Gastroenterol 49(4):655–666
Yan C, Yang J, Shen L, Chen X (2012) Inhibitory effect of epigallocatechin gallate on ovarian cancer cell proliferation associated with aquaporin 5 expression. Arch Gynecol Obstet 285(2):459–467
Yang J, Yan C, Zheng W, Chen X (2012) Proliferation inhibition of cisplatin and aquaporin 5 expression in human ovarian cancer cell CAOV3. Arch Gynecol Obstet 285(1):239–245
Chen X, Yang J, Zheng W (2009) Effect of topotecan on expression of aquaporin protein 5 and nuclear factorB! B in ovarian cancer SKOV3 cells. Chi J Cancer 28(8)
Yang J-H, Shi Y-F, Cheng Q, Deng L (2006) Expression and localization of aquaporin-5 in the epithelial ovarian tumors. Gynecol Oncol 100(2):294–299
Yan C, Zhu Y, Zhang X, Chen X, Zheng W, Yang J (2014) Down-regulated aquaporin 5 inhibits proliferation and migration of human epithelial ovarian cancer 3AO cells. J Ovarian Res 7(1):78
Jung HJ, Park J-Y, Jeon H-S, Kwon T-H (2011) Aquaporin-5: a marker protein for proliferation and migration of human breast cancer cells. PLoS One 6(12):e28492
Jensen HH, Login FH, Park J-Y, Kwon T-H, Nejsum LN (2017) Immunohistochemical evalulation of activated Ras and Rac1 as potential downstream effectors of aquaporin-5 in breast cancer in vivo. Biochem Biophys Res Commun 493(3):1210–1216
Lee SJ, Chae YS, Kim JG, Kim WW, Jung JH, Park HY, Jeong JY, Park JY, Jung HJ, Kwon TH (2014) AQP5 expression predicts survival in patients with early breast cancer. Ann Surg Oncol 21(2):375–383
Zhu Z, Jiao L, Li T, Wang H, Wei W, Qian H (2018) Expression of AQP3 and AQP5 as a prognostic marker in triple-negative breast cancer. Oncol Lett 16(2):2661–2667
Guo K, Jin F (2015) NFAT5 promotes proliferation and migration of lung adenocarcinoma cells in part through regulating AQP5 expression. Biochem Biophys Res Commun 465(3):644–649
Zhang Z-Q, Zhu Z-X, Bai C-X, Chen Z-H (2011) Aquaporin 5 expression increases mucin production in lung adenocarcinoma. Oncol Rep 25(6):1645–1650
Moon C, Soria J-C, Jang SJ, Lee J, Hoque MO, Sibony M, Trink B, Chang YS, Sidransky D, Mao L (2003) Involvement of aquaporins in colorectal carcinogenesis. Oncogene. 22(43):6699–6703
Chen C, Ma T, Zhang C, Zhang H, Bai L, Kong L, Luo J (2017) Down-regulation of aquaporin 5-mediated epithelial-mesenchymal transition and anti-metastatic effect by natural product Cairicoside E in colorectal cancer. Mol Carcinog 56(12):2692–2705
Shi X, Wu S, Yang Y, Tang L, Wang Y, Dong J, Lü B, Jiang G, Zhao W (2014) AQP5 silencing suppresses p38 MAPK signaling and improves drug resistance in colon cancer cells. Tumor Biol 35(7):7035–7045
Guo X, Sun T, Yang M, Li Z, Li Z, Gao Y (2013) Prognostic value of combined aquaporin 3 and aquaporin 5 overexpression in hepatocellular carcinoma. Biomed Res Int 2013:1–7
He Z, Dong W, Hu J, Ren X (2017) AQP5 promotes hepatocellular carcinoma metastasis via NF-κB-regulated epithelial-mesenchymal transition. Biochem Biophys Res Commun 490(2):343–348
Kudou M, Shiozaki A, Kosuga T, Shimizu H, Ichikawa D, Konishi H, Morimura R, Komatsu S, Ikoma H, Fujiwara H, Okamoto K, Marunaka Y, Otsuji E (2017) Heat shock exerts anticancer effects on liver cancer via autophagic degradation of aquaporin 5. Int J Oncol 50(5):1857–1867
Pust A, Kylies D, Hube-Magg C, Kluth M, Minner S, Koop C, Grob T, Graefen M, Salomon G, Tsourlakis MC, Izbicki J, Wittmer C, Huland H, Simon R, Wilczak W, Sauter G, Steurer S, Krech T, Schlomm T, Melling N (2016) Aquaporin 5 expression is frequent in prostate cancer and shows a dichotomous correlation with tumor phenotype and PSA recurrence. Hum Pathol 48:102–110
Watanabe T, Fujii T, Oya T, Horikawa N, Tabuchi Y, Takahashi Y, Morii M, Takeguchi N, Tsukada K, Sakai H (2009) Involvement of aquaporin-5 in differentiation of human gastric cancer cells. J Physiol Sci 59(2):113–122
Huang Y-H, Zhou X-Y, Wang H-M, Xu H, Chen J, Lv N-H (2013) Aquaporin 5 promotes the proliferation and migration of human gastric carcinoma cells. Tumor Biol 34(3):1743–1751
Verkman A (2009) Aquaporins: translating bench research to human disease. J Exp Biol 212(11):1707–1715
Nico B, Ribatti D (2010) Aquaporins in tumor growth and angiogenesis. Cancer Lett 294(2):135–138
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Moosavi, MS., Elham, Y. Aquaporins 1, 3 and 5 in Different Tumors, their Expression, Prognosis Value and Role as New Therapeutic Targets. Pathol. Oncol. Res. 26, 615–625 (2020). https://doi.org/10.1007/s12253-019-00646-9
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DOI: https://doi.org/10.1007/s12253-019-00646-9