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Differing Lymphatic Vessels Density in Salivary Adenoid Cystic Carcinoma and Pleomorphic Adenoma

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Pathology & Oncology Research

Abstract

Benign and malignant tumours are known to express various factors inducing lymphangiogenesis. Despite their different biological behaviour, salivary pleomorphic adenomas (PA) and adenoid cystic carcinomas (SACC) show similar lymphatic network. Authors compare density of lymphatic network in these tumours. The retrospective study included 20 SACC and 20 PA from salivary tumours. Lymphatic vessel density (LVD) was identified using D2-40 antibody and counted. In SACC, intratumoral, respectively peritumoral, lymphatic vessels were identified in 100 %, respectively 93.8 %, of cases. The intratumoral and peritumoral LVD did not significantly differ from each other. However, they both were higher than normal parenchyma density. In PA, intratumoral LVD, with a single exception, revealed values of 0 and 1. The intratumoral was found to be lower than peritumoral density. The LVD in healthy gland, similar to peritumoral one, was significantly higher than intratumoral values. Direct comparison showed intratumoral and peritumoral LVD in PA to be lower than in SACC. This study comparing LVD in PA and SACC revealed higher values in SACC, outnumbering those in healthy salivary parenchyma and PA. It suggests the capability of this biologically aggressive neoplasm to induce lymphangiogenesis.

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Acknowledgments

This study was supported the Internal Grant Agency of the Ministry of Health, Czech Republic, Nr. NT13701-4/2012, RVO-FNOL2016 and RVO 61989592. Mr. George Kumsta is acknowledged for his help with the final English revision.

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Authors and Affiliations

  1. Department of Otorhinolaryngology, Faculty of Medicine and Dentistry, Palacky University Olomouc, University Hospital Olomouc, I. P. Pavlova 6, 775 20, Olomouc, Czech Republic

    Richard Salzman & I. Stárek

  2. Department of Clinical and Molecular Pathology, Faculty of Medicine and Dentistry, Palacky University Olomouc, University Hospital Olomouc, I. P. Pavlova 6, 775 20, Olomouc, Czech Republic

    L. Kučerová

  3. Department of Pathology, Charles University in Prague, Alej svobody 80, 304 60, Pilsen, Czech Republic

    A. Skálová

Authors
  1. Richard Salzman
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  2. I. Stárek
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  3. L. Kučerová
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  4. A. Skálová
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Correspondence to Richard Salzman.

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Funding

This study was supported the Internal Grant Agency of the Ministry of Health, Czech Republic, Nr. NT13701-4/2012 and RVO 61989592.

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The authors declare that they have no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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For this type of study formal informed consent is not required.

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The first 2 authors contributed equally to the preparation of the manuscript.

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Salzman, R., Stárek, I., Kučerová, L. et al. Differing Lymphatic Vessels Density in Salivary Adenoid Cystic Carcinoma and Pleomorphic Adenoma. Pathol. Oncol. Res. 23, 545–550 (2017). https://doi.org/10.1007/s12253-016-0147-5

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  • DOI: https://doi.org/10.1007/s12253-016-0147-5

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