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Poly(N-vinyl caprolactam-co-maleic anhydride)-Grafted Cotton Gauze with Antimicrobial Properties for Their Potential Use as Wound Dressings

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Abstract

Medical cotton gauzes were modified by grafting poly(N-vinylcaprolactam-co-maleic anhydride) (gauze-g-(PVCL-co-MA)) through free radical polymerization to prepare a novel wound dressing with antimicrobial and drug delivery capabilities. Several gauze-g-(PVCL-co-MA) were synthesized, each characterized by distinct grafting percentage of 23, 40, and 100% labeled as VMG1, VMG2, and VMG3, respectively. Polymer grafting was verified using methods such as Fourier Transform Infrared Spectroscopy (FT-IR), Thermogravimetric analysis (TGA), Scanning Electronic Microscopy (SEM), and swelling studies. The grafted cotton gauzes were loaded with vancomycin and tested as drug-eluting systems, exhibited considerable loading capacity and over 80% release. The antibacterial activity was evaluated against S. aureus (ATCC 29213) according to the Japanese Industrial Standard JIS Z 2801 method. They showed growth inhibition for this microorganism. Moreover, they showed good biocompatibility for the 1132SK and SaOS-2 cell lines. These results suggest that the gauze-g-(PVCL-co-MA) could be used as antimicrobial and drug-eluting wound dressings in the biomedical field.

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Data availability

The data supporting this study's findings are available from the corresponding author, Carrillo-Rodríguez J.C., upon reasonable request.

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Acknowledgements

This work was supported by CONACyT [Ciencia de Frontera 2019 6660] and COECyT [COAH-2022-C19-CO39]; H.I. Meléndez-Ortiz is particularly grateful to the program “Investigadoras e Investigadores por México” (CONAHCyT, Mexico). The authors also thank J.A. Mercado-Silva, C.N. Alvarado-Canche, and Laboratorio de análisis de cultivo celular del DMA de CIQA for their technical assistance.

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Authors and Affiliations

  1. Centro de Investigación en Química Aplicada, Blvd. Enrique Reyna Hermosillo #140, 25294, Saltillo, Coahuila, Mexico

    R. Betancourt-Galindo, J. C. Carrillo-Rodríguez, B. Puente-Urbina, R. Espinosa-Neira & A. Ledezma

  2. CONACyT-Centro de Investigación en Química Aplicada, Blvd. Enrique Reyna Hermosillo #140, 25294, Saltillo, Coahuila, Mexico

    H. Ivan Meléndez-Ortiz

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  1. R. Betancourt-Galindo
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Contributions

All authors contributed to the study's conception and design. Material preparation, data collection and analysis were performed by R. Bentacourt-Galindo, H. Ivan Meléndez-Ortiz, B. Puente-Urbina, A. Ledezma, and R. Espinosa-Neira. J.C. Carrillo-Rodríguez wrote the first draft of the manuscript, and all authors commented on previous versions. All authors read and approved the final manuscript.

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Correspondence to J. C. Carrillo-Rodríguez.

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Betancourt-Galindo, R., Carrillo-Rodríguez, J.C., Meléndez-Ortiz, H.I. et al. Poly(N-vinyl caprolactam-co-maleic anhydride)-Grafted Cotton Gauze with Antimicrobial Properties for Their Potential Use as Wound Dressings. Fibers Polym 25, 933–943 (2024). https://doi.org/10.1007/s12221-024-00490-y

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