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Incorporation of Hydroxyapatite/Doxorubicin into the Chitosan/Polyvinyl Alcohol/Polyurethane Nanofibers for Controlled Release of Doxurubicin and Its Anticancer Property

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Abstract

In the present study, the doxorubicin-hydroxyapatite (DOX-HAp) has been loaded into the chitosan/PVA/PU single layer and core-shell nanofibers. The potential of synthesized nanofibers was evaluated for controlled release of DOX and bone cancer treatment in vitro. The synthesized DOX-HAp nanohybrid was characterized using XRD, SEM, and UV-Vis analysis. The morphology of synthesized nanofibers was examined by SEM and TEM analysis. For single layer nanofibers, some DOX-HAp nanohybrids were observed on the nanofibers surface. The fiber diameter was increased by increasing shell flow rate and no DOX-HAp nanohybrids were detected on the core-shell fibers surface. The DOX encapsulation efficiency of single layer and core-shell layer fibers was higher than 90 %. The initial burst release from single layer fiber at initial hours and the continuous release of DOX was observed from single layer nanofibers during 7 and 10 days under acidic and physiological pH. The sustained release of DOX was obtained within 10 and 14 days, 15 and 18 days, 21 and 25 days from core-shell fibers with flow rates of 0.3, 0.5 and 0.8 ml/h under acidic and physiological pH. The non-Fickian diffusion and Fickian diffusion were achieved from single layer and core-shell nanofibers. The cell attachment and cell death results indicated the high potential of DOX loaded-core-shell fibers for bone cancer treatment.

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Acknowledgment

The authors would like to acknowledge the financial support of Islamic Azad University, Birjand branch, for the research project.

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Authors and Affiliations

  1. Textile Engineering Department, Birjand Branch, Islamic Azad University, Birjand, 9717711111, Iran

    Sayyed Sadroddin Qavamnia

  2. Department of Chemistry, Guilan Science and Research Branch, Islamic Azad University, Guilan, Iran

    Leila Roshanfekr Rad

  3. Faculty of Pharmacy, Alborz University of Medical Sciences, Karaj, Iran

    Mohammad Irani

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  1. Sayyed Sadroddin Qavamnia
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  2. Leila Roshanfekr Rad
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  3. Mohammad Irani
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Correspondence to Sayyed Sadroddin Qavamnia or Mohammad Irani.

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Qavamnia, S.S., Rad, L.R. & Irani, M. Incorporation of Hydroxyapatite/Doxorubicin into the Chitosan/Polyvinyl Alcohol/Polyurethane Nanofibers for Controlled Release of Doxurubicin and Its Anticancer Property. Fibers Polym 21, 1634–1642 (2020). https://doi.org/10.1007/s12221-020-9809-8

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