Abstract
In this study, we evaluated hemodynamics using simulated models and determined how cerebral aneurysms develop in simulated and patient-specific models based on medical images. Computational fluid dynamics (CFD) was analyzed by use of OpenFOAM software. Flow velocity, stream line, and wall shear stress (WSS) were evaluated in a simulated model aneurysm with known geometry and in a three-dimensional angiographic model. The ratio of WSS at the aneurysm compared with that at the basilar artery was 1:10 in simulated model aneurysms with a diameter of 10 mm and 1:18 in the angiographic model, indicating similar tendencies. Vortex flow occurred in both model aneurysms, and the WSS decreased in larger model aneurysms. The angiographic model provided accurate CFD information, and the tendencies of simulated and angiographic models were similar. These findings indicate that hemodynamic effects are involved in the development of aneurysms.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Kumar V, Cotran SR, Robbins LS. Robbins basic pathology. 7th ed. Philadelphia: Elsevier Saunders; 2003. p. 409–54.
Nagahiro S, Satoh K, Nakajima N, Hamada J, Ushio Y. Growth mechanism and treatment of partially thrombosed giant aneurysm. Jpn J Neurosurg. 2001;10:10–7.
Yasukawa K, Kamijo Y, Momose G, Kobayashi S, Ikeda A. A case of anterior cerebral artery dissecting aneurysm presenting subarachnoid hemorrhage and cerebral infarction at the same time. Surg Cereb Stroke. 1993;21:461–6.
Hoi Y, Meng H, Woodward SH, Bendok BR, Hanel RA, Guterman LR, Hopkins LN. Effects of arterial geometry on aneurysm growth: three-dimensional computational fluid dynamics study. J Neurosurg. 2004;101:676–81.
Nakatani H, Hashimoto N, Kang Y. Cerebral blood flow patterns at major vessel bifurcations and aneurysms in rats. J Neurosurg. 1991;74:258–62.
Gonzalez CF, Choi YI, Ortega V. Intracranial aneurysms: flow analysis of their origin and progression. Am J Neuroradiol. 1992;13:181–8.
Jameson A, Martinelli L, Pierce NA. Optimum aerodynamic design using the Navier-Stokes equations. Theoret Comput Fluid Dyn. 1998;10:213–37.
Endo T, Matsuoka S, Hashizume N, Nagasaka M. Performance evaluation of TSUBAME heterogeneous supercomputer with linpack. Inf Process Soc Jpn. 2007;48:62–70.
Zhang Y, Furusawa T, Sia SF, Umezu M, Qian Y. Proposition of an outflow boundary approach for carotid artery stenosis CFD simulation. Comput Methods Biomech Biomed Eng. 2013;16:488–94.
Steinman D, Milner J, Norley JC, Lownie S, Holdsworth WD. Image-based computational simulation of flow dynamics in a giant intracranial aneurysm. Am J Neuroradiol. 2003;24:559–66.
Papathanasopoulou P, Zhao S, Köhler U, Robertson MB, Long Q, Hoskins P, Xu XY, Marshall I. MRI measurement of time-resolved wall shear stress vectors in a carotid bifurcation model, and comparison with CFD predictions. J Magn Reson Imag. 2003;17:153–62.
Raj S, Irani FG, Tay KH, Tan BS. C-arm cone beam computed tomography: a new tool in the interventional suite. Ann Acad Med. 2013;42:585–92.
Fiorella D, Arthur A, Schafer S. Minimally invasive cone beam CT-guided evacuation of parenchymal and ventricular hemorrhage using the Apollo system: proof of concept in a cadaver model. J NeuroIntervent Surg. 2014;0:1–5. doi:10.1136/neurintsurg-2014-011293.
White PM, Wardlaw JM. Unruptured intracranial aneurysms. J Neuroradiol. 2003;30:336–50.
Ujiie H, Tamano Y, Sasaki K, Hori T. Is the aspect ratio a reliable index for predicting the rupture of a saccular aneurysm? Neurosurgery. 2001;48:495–503.
Ma B, Harbaugh RE, Raghavan ML. Three-dimensional geometrical characterization of cerebral aneurysms. Ann Biomed Eng. 2004;32:264–73.
Millan D, Dempere ML, Pozo JM, Cebral JR, Frangi AF. Morphological characterization of intracranial aneurysms using 3-D moment invariants. IEEE Trans Med Imag. 2007;26:1270–82.
Saho T, Onishi H, Sugihara T, Nakamura Y, Yuda I. Tackling hemodynamic analysis of the carotid artery using open-source software and computational fluid dynamics. Jpn J Radiol Technol. 2012;69:1241–9.
Nixon AM, Gunel M, Sumpio BE. The critical role of hemodynamics in the development of cerebral vascular disease. J Neurosurg. 2010;112:1240–53.
The OpenCFD Foundation. OpenFOAM Users Guide Ver 2.3.1 3rd December 2014. Paris: OpenCFD Foundation; 2014.
Castro MA, Putman CM, Cebral JR. Computational fluid dynamics modeling of intracranial aneurysms: effects of parent artery segmentation on intra-aneurysmal hemodynamics. Am J Neuroradiol. 2006;27:1703–9.
Yamamoto S, Maruyama S, Nakahara Y, Yoneyama S, Tanifuji S, Wada S, Hamada S, Komizu M, Johkoh T, Yamaguchi M, Doi M, Yamaguchi T. Abdominal aortic aneurysm using multislice computed tomography. Computed flow dynamics in abdominal aortic aneurysm using multislice computed tomography. Jpn J Radiol Technol. 2006;62:115–21.
Soustiel FJ, Shik V, Shreiber R, Tavor Y, Goldsher D. Basilar vasospasm diagnosis investigation of a modified “Lindegaard Index” based on imaging studies and blood velocity measurements of the basilar artery. Stroke. 2002;33:72–8.
Caretto LS, Gosman AD, Patankar SV, Spalding DB. Two calculation procedures for steady, three-dimensional flows with recirculation. Third Int Conf Numer Methods Fluid Mech. 1973;19:60–8.
Yin R, Chow KW. Comparison of four algorithms for solving pressure-velocity linked equations in simulating atrium fire. Int J Archit Sci. 2003;4:24–35.
Conflict of interest
The authors declare that they have no conflict of interest.
Author information
Authors and Affiliations
Corresponding author
About this article
Cite this article
Saho, T., Onishi, H. Quantitative comparison of hemodynamics in simulated and 3D angiography models of cerebral aneurysms by use of computational fluid dynamics. Radiol Phys Technol 8, 258–265 (2015). https://doi.org/10.1007/s12194-015-0315-4
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12194-015-0315-4