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Retrospective analysis of plasmacytoma in Kansai Myeloma Forum Registry

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Abstract

We retrospectively analyzed 51 patients with solitary plasmacytoma diagnosed from October 2002 to September 2018 from a cohort of 3575 patients with plasma cell dyscrasias registered in the Kansai Myeloma Forum. Twenty-seven patients had solitary bone plasmacytoma (SBP) and 24 had extramedullary plasmacytoma (EMP), with prevalence of 0.8% and 0.7%, respectively. The most frequent M protein was IgG (40%) in SBP, whereas non-secretory proteins were most frequent (50%) in EMP. Five-year overall survival was 78.2% in SBP and 80.8% in EMP (P = 0.894). Among patients with SBP, 44% progressed to MM with a median time of 10.5 months (2.4–93.3 months), whereas 8% of EMP patients progressed to MM with a median time of 18.6 months (13.0–24.2 months). The most frequent treatment was radiotherapy (41%) or observation (41%) in SBP, and chemotherapy (54%) in EMP. No statistically significant difference was observed upon univariate analysis of prognostic factors including age, sex, performance status, and IgG M protein. Our results suggest that there are biological differences between SBP and EMP in real-world settings.

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Acknowledgements

The authors would like to thank all myeloma patients registered in KMF and all KMF investigators for their scientific support. We also thank Ms. Okuyama R for her assistance.

Author information

Authors and Affiliations

  1. Division of Hematology, First Department of Internal Medicine, Kansai Medical University Medical Center, 10-15 Fumizono-cho, Moriguchi-city, Osaka, 570-8507, Japan

    Aya Nakaya & Shosaku Nomura

  2. Department of Hematology and Rheumatology, Faculty of Medicine, Kindai University, Osaka, Japan

    Hirokazu Tanaka & Itaru Matsumura

  3. Department of Hematology and Oncology, Nara Prefecture General Medical Center, Nara, Japan

    Hideo Yagi

  4. Hematology Ohta Clinic, Shinsaibashi, Osaka, Japan

    Kensuke Ohta

  5. Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Osaka, Japan

    Hirohiko Shibayama, Takae Kohara & Yuzuru Kanakura

  6. Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

    Junya Kanda, Maki Shindo & Akifumi Takaori-Kondo

  7. Division of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan

    Yuji Shimura & Junya Kuroda

  8. Department of Internal Medicine (Hematology), Toyonaka Municipal Hospital, Osaka, Japan

    Satoru Kosugi & Toru Kida

  9. Department of Hematology, Japanese Red Cross Osaka Hospital, Osaka, Japan

    Hitomi Kaneko & Kazunori Imada

  10. Department of Hematology, Rinku General Medical Center, Osaka, Japan

    Takahiro Karasuno

  11. Department of Hematology, PL General Hospital, Osaka, Japan

    Mitsuhiro Matsuda

  12. Kawasaki Hospital, Internal Medicine, Hyogo, Japan

    Masato Iida

  13. Department of Internal Medicine, JCHO Kobe Central Hospital, Hyogo, Japan

    Yoko Adachi

  14. Department of Hematology, Japan Community Health Care Organization Kyoto Kuramaguchi Medical Center, Kyoto, Japan

    Shin-ichi Fuchida & Chihiro Shimazaki

  15. Department of Hematology, Japanese Red Cross Kyoto Daini Hospital, Kyoto, Japan

    Nobuhiko Uoshima

  16. Department of Hematology, Japanese Red Cross Kyoto Daiichi Hospital, Kyoto, Japan

    Hitoji Uchiyama

  17. Department of Hematology, Omihachiman Community Medical Center, Shiga, Japan

    Ryoichi Takahashi

  18. Department of Hematology, Nishiwaki Municipal Hospital, Hyogo, Japan

    Toshimitsu Matsui

  19. Department of Hematology, Matsushita Memorial Hospital, Osaka, Japan

    Katsuya Wada & Miki Kiyota

  20. Kansai Myeloma Forum, Osaka, Japan

    Aya Nakaya, Hirokazu Tanaka, Hideo Yagi, Kensuke Ohta, Hirohiko Shibayama, Takae Kohara, Junya Kanda, Maki Shindo, Yuji Shimura, Satoru Kosugi, Toru Kida, Hitomi Kaneko, Kazunori Imada, Takahiro Karasuno, Mitsuhiro Matsuda, Masato Iida, Yoko Adachi, Shin-ichi Fuchida, Nobuhiko Uoshima, Hitoji Uchiyama, Ryoichi Takahashi, Toshimitsu Matsui, Katsuya Wada, Miki Kiyota, Chihiro Shimazaki, Masayuki Hino, Junya Kuroda, Yuzuru Kanakura, Akifumi Takaori-Kondo, Shosaku Nomura & Itaru Matsumura

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  1. Aya Nakaya
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Kansai Myeloma Forum Investigators

Contributions

AN and HS designed the study. AN performed statistical analysis and interpretation of data, drafted the article. HS and YK revised the article. HY, HK, SK, TK, YA, TK, YK, SF, NU, EK, HU, YS, TT, FU, KO, TH, KM, MK, MS, HT, CS, MH, JK, ATK, SN, IM provided patient data. All co-authors approved the final version of the manuscript.

Corresponding author

Correspondence to Aya Nakaya.

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Conflict of interest

All authors received research funding from Celgene Co., Ltd., Takeda Pharmaceutical Co., Fujimoto Pharmaceutical Co., and Ono Pharmaceutical Co. HT, HS, MH, AT, IM, KI received honoraria from Novartis Pharmaceuticals Co. JKU, HS, AT received honoraria from Janssen Pharmaceuticals. JKU, AT, IM, KI received honoraria from Bristol-Myers Squibb. JKU, HS, IM, KI received honoraria from Takeda Pharmaceutical Co. HS, KI received honoraria from Kyowa Hakko Kirin Co. HS, KI received honoraria from Chugai Pharmaceutical Co. MH, IM received honoraria from Pfizer, Inc. MH received honoraria from Merck & Co. IM received honoraria from AbbVie GK. KI received honoraria from Nippon Shinyaku, Otsuka Pharmaceutical Co, Sumitomo Dainippon Pharma, Astellas Pharma, Shire Japan. JKU, AT received research funding from Bristol-Myers Squibb. JKU received research funding from Sysmex Co. AT received research funding from COGNANO Co, Sumitomo Dainippon Pharma, Thyas Co, OHARA Pharmaceutical Co. Kinshikouraininjin. IM, YK received research funding from Chugai Pharmaceutical Co. IM received research funding from Pfizer, Inc, Eisai Co., Merck and Co., Nippon Shinyaku, Otsuka Pharmaceutical Co., Mundipharma K.K. YK received research funding from Alexion Pharma. HS received research funding from Takeda Pharmaceutical Co., Janssen Pharmaceuticals, Novartis Pharmaceuticals Co., Sanofi K.K., AstraZeneca K.K., AbbVie GK., IQVIA Services Japan K.K

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Nakaya, A., Tanaka, H., Yagi, H. et al. Retrospective analysis of plasmacytoma in Kansai Myeloma Forum Registry. Int J Hematol 112, 666–673 (2020). https://doi.org/10.1007/s12185-020-02961-3

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