Abstract
The prognostic impact of extramedullary plasmacytomas (EMPs) on newly diagnosed symptomatic multiple myeloma (MM) was evaluated in the context of treatment approach including autologous stem cell transplantation (ASCT) and chemotherapy alone. A total of 275 consecutive patients with newly diagnosed MM were included, and 54 patients (19.6 %) had EMPs at diagnosis. Patients with initial EMPs were more likely to have myeloma bone disease but favorable laboratory parameters in hemoglobin and β2-microglobulin. Patients were treated with different schemas based on transplant eligibility (154 in ASCT-eligible vs. 121 in ASCT-ineligible). After a median follow-up of 24.6 months (range, 0.2–56.3 months) in survivors, patients with initial EMPs had significantly worse progression-free survival (PFS) (P = 0.035) and overall survival (OS) (P = 0.006) compared to those without initial EMPs. In the multivariate analyses, the presence of initial EMPs was an independent prognostic factor for PFS (relative risk (RR) of 2.24, P = 0.024) and OS (RR of 2.47, P = 0.027) in the transplant-ineligible patients, whereas it did not significantly influence PFS (P = 0.341) or OS (P = 0.499) in the transplant-eligible patients. However, the adverse impact of EMPs observed in transplant-ineligible patients was attenuated among the patients treated with bortezomib. These data suggest that ASCT can overcome the negative impact of EMPs and highlight the potential efficacy of bortezomib on EMPs in the non-transplant setting.
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Acknowledgments
The authors acknowledge all members at the Catholic Blood and Marrow Transplantation Center, particularly the house staff, for their excellent care of the patients. This study was supported by the Korea Healthcare Technology R&D Project, Ministry of Health& Welfare, Republic of Korea (A120175).
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Supplementary Fig. 1
Treatment schedule (GIF 324 kb)
Supplementary Fig. 2
Influence of EMPs at diagnosis on survival outcome in transplant-ineligible patients treated with bortezomib-based regimens. a Probabilities of overall survival and b probabilities of progression-free survival (GIF 295 kb)
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Lee, SE., Kim, JH., Jeon, YW. et al. Impact of extramedullary plasmacytomas on outcomes according to treatment approach in newly diagnosed symptomatic multiple myeloma. Ann Hematol 94, 445–452 (2015). https://doi.org/10.1007/s00277-014-2216-8
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DOI: https://doi.org/10.1007/s00277-014-2216-8