Abstract
Ion mobility spectrometry (IMS) was used for determination of the histamine content in samples of tuna stomach, and the results were compared with measurements by high-pressure liquid chromatography (HPLC) that is considered the “gold standard” method. The production of histamine as a function of storage time at ambient temperature (25–29 °C) was followed by both methods and a good correlation was found between them. The results were validated by IMS and HPLC measurements of samples of fresh tuna fillets in which the initial histamine level was below 10 mg histamine per kg (10 ppm). The level gradually increased to thousands of milligrams per kilogram after about 30 h at ambient temperature. In the IMS measurements, the intensity ratio between the fragment ion of histamine (K 0 = 2.73 cm2 V−1 s−1) and the sum of all the ions in the mobility spectrum served to quantify the histamine level in the fish samples. Thus, a rapid, simple, and inexpensive method was developed for determination of histamine in tuna.
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Acknowledgments
We wish to thank Dr. Noa Tejman and Dr. Irena Lavelin from the Ministry of Health Southern District, Public Health Laboratory in Beer-Sheva, for their cooperation and performance of the HPLC measurements.
Compliance with Ethics Requirements
The authors state that the manuscript has been prepared with strict observation of the ethical responsibilities of all the authors. This article does not contain any studies with human or animal subjects.
Conflict of Interest
Gabi Cohen declares that he has no conflict of interest. Denis Danny Rudnik declares that he has no conflict of interest. Mordi Laloush declares that he has no conflict of interest. Doron Yakir declares that he has no conflict of interest. Zeev Karpas declares that he has no conflict of interest.
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Cohen, G., Rudnik, D.D., Laloush, M. et al. A Novel Method for Determination of Histamine in Tuna Fish by Ion Mobility Spectrometry. Food Anal. Methods 8, 2376–2382 (2015). https://doi.org/10.1007/s12161-015-0129-3
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DOI: https://doi.org/10.1007/s12161-015-0129-3