Abstract
Collision tumors, composed of two distinct benign or malignant neoplasms, are rarely reported in the oral cavity. We present a case of a 61-year-old female with an asymptomatic non-demarcated lump on the soft palate of unknown duration. An incisional biopsy revealed the presence of two neoplastic populations, a neurofibroma that was partially infiltrated by a polymorphous adenocarcinoma, low-grade variant. Total surgical excision was performed, with uneventful follow-up period. The development of collision tumors may be incidental, although molecular events may influence the pathogenetic mechanism of the phenomenon.
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The data including clinical information, radiograph, and histopathologic preparations are available upon request.
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The study was funded by the University of Minnesota Oral Pathology Research Fund (internal funding).
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NGK was the primary author of the paper. KIT and IGK designed the study, analyzed the data, authored parts of the paper. IGK is also the corresponding author. HAL and RU performed the incisional biopsy and, subsequently, performed the surgery. The paper was critically reviewed and approved by all authors.
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The study was performed in accordance with the 1964 Helsinki Declaration standards.
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Katsoulas, N.G., Tosios, K.I., Lynch, H.A. et al. Polymorphous Adenocarcinoma, Low Grade Variant, Colliding with a Neurofibroma. Head and Neck Pathol 16, 602–606 (2022). https://doi.org/10.1007/s12105-021-01377-7
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DOI: https://doi.org/10.1007/s12105-021-01377-7