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Ovarian collision tumors: imaging findings, pathological characteristics, diagnosis, and differential diagnosis

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Abstract

Collision tumors are uncommon neoplasms in which elements of differing histologic origins coexist in a single mass. Ovarian collision tumors are a rare subtype of such lesions. The identification of collision tumors by radiologic examinations is essential to ensure that comprehensive biopsies are performed to guide appropriate treatments. According to the clinical and imaging findings of 12 patients and reviews of previous studies, ovarian collision tumors are mixtures of different combinations of epithelial tumors, germ cell tumors, and sex-cord-stromal tumors. The smaller tumors are usually located inside (“nested tumor”) or on the wall (“back to back”) of the larger tumors. Each type of ovarian collision tumors presents specific CT/MRI features in accordance with their histologic origins and collision patterns. Knowledge of the imaging features of ovarian collision tumors is crucial to aid preoperative diagnostic accuracy.

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Author notes

  1. Yang Peng and Jinhua Lin contributed equally to this work, and they are co-first authors.

Authors and Affiliations

  1. Department of Radiology, The First Affiliated Hospital of Sun Yat-Sen University, 58 Zhongshan Road 2, Guangzhou, Guangdong, People’s Republic of China

    Yang Peng, Jian Guan, Xiaoling Zhang, Shurong Li, Huanjun Wang, Mingjuan Liu & Yan Guo

  2. Department of Medical Ultrasound, Institute of Diagnostic and Interventional Ultrasound, The First Affiliated Hospital of Sun Yat-Sen University, 58 Zhongshan Road 2, Guangzhou, Guangdong, People’s Republic of China

    Jinhua Lin

  3. Department of Pathology, The First Affiliated Hospital of Sun Yat-Sen University, 58 Zhongshan Road 2, Guangzhou, Guangdong, People’s Republic of China

    Lili Chen

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  1. Yang Peng
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Correspondence to Jian Guan.

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Conflict of interest

The authors declare that they have no conflict of interests. The authors state that this work was funded by National Natural Science Foundation of China (No. 81701747, Huanjun Wang), Natural Science Foundation of Guangdong Province, China (2017A030313902, Huanjun Wang) and Science and Technology Planning Project of Guangdong Province, China (2013B021800136, Jian Guan). One of the authors has significant software programing expertise.

Disclosure

The scientific guarantor of this publication is Jian Guan.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research ethics committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. For this type of study, formal consent is not required.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Methodology

Retrospective, Diagnostic study, Performed at one institution.

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Peng, Y., Lin, J., Guan, J. et al. Ovarian collision tumors: imaging findings, pathological characteristics, diagnosis, and differential diagnosis. Abdom Radiol 43, 2156–2168 (2018). https://doi.org/10.1007/s00261-017-1419-6

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