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Secretory Carcinoma of the Oral Cavity: A Retrospective Case Series with Review of Literature

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Abstract

Secretory carcinoma (SC) is an uncommon salivary gland neoplasm of the oral cavity that microscopically may mimic acinic cell carcinoma (ACC) and mucoepidermoid carcinoma (MEC). This study describes a series of SC in minor glands with a literature review. We performed a retrospective search for oral SC, within the archives of the University of Florida, Oral Pathology and Surgical Pathology Biopsy services from 2010 to 2018. A total of 10 SCs were identified in the oral and maxillofacial region, four of which were in the minor salivary glands. The demographic, clinical, histological, and molecular findings were aggregated for all 4 cases. Patient age varied from 30 to 60 years, with an average of 45 years. Two cases each were in female and male patients. Two cases presented on the labial mucosa, and one each on the hard and soft palate. Immunohistochemical (IHC) staining showed mammaglobin positivity in all cases, GATA3 positivity in two cases, S100 positivity in three cases, and SOX10 positivity in only one case. Fluorescence in situ hybridization demonstrated positivity for ETV6-NTRK3 fusion in 4 cases. Although oral SC is rare, pathologists should be aware of the histologic overlap between the SC and other salivary gland neoplasms such as ACC and MEC. A judicious application of IHC staining would aid in diagnosis. SC should be considered in the differential diagnosis for intraoral salivary gland tumors.

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Acknowledgements

We thank Stacy Hicks – MS, CG (ASCP) CM-in UPMC Presbyterian/Shadyside Anatomic Pathology, in situ Hybridization Laboratory, for performing fluorescence in situ hybridization and imaging. Robert N.Levenson and Frace B. Dunlevy Oral Pathology Research Funds.

Funding

Funding was provided by Robert N. Levenson and Frace B. Dunlevy Oral Pathology Research Funds.

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Authors and Affiliations

  1. Department of Oral and Maxillofacial Diagnostic Sciences, University of Florida College of Dentistry, 1395 Center Drive, Gainesville, FL, 32610, USA

    Shankar Venkat, Sarah Fitzpatrick, Indraneel Bhattacharyya, Donald M. Cohen & Mohammed N. Islam

  2. Department of Pathology, Immunology and Laboratory Medicine College of Medicine, 1395 Center Drive, Gainesville, FL, 32610, USA

    Peter A. Drew

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  1. Shankar Venkat
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  2. Sarah Fitzpatrick
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Correspondence to Shankar Venkat.

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The study was approved by University of Florida IRB201801970 and consent was waived under the IRB guidelines.

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Venkat, S., Fitzpatrick, S., Drew, P.A. et al. Secretory Carcinoma of the Oral Cavity: A Retrospective Case Series with Review of Literature. Head and Neck Pathol 15, 893–904 (2021). https://doi.org/10.1007/s12105-021-01310-y

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  • DOI: https://doi.org/10.1007/s12105-021-01310-y

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