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Low-Grade Papillary Schneiderian Carcinoma: Report of a Case with Molecular Characterization

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Abstract

In 2015, Lewis et al. first described low-grade papillary Scheneiderian carcinoma (LGPSC) of the sinonasal tract. Their case resembled a sinonasal papilloma clinically and histopathologically; however, invasion and metastasis resulted in the death of the patient despite absence of malignant cytologic features. Additional reports established LGPSC as a distinct entity and characterized its immunohistochemical profile. Diffuse expression of low molecular weight cytokeratins, positivity for p16 and p53 in at least 50% of cells, a high Ki-67 index, and absence of human papillomavirus (HPV)-DNA was observed across all reported cases. We report an additional case of LGPSC and describe the clinical, histologic, and immunohistochemical features. In contrast to sinonasal papillomas, the case was negative for HPV-DNA and showed no mutations in the EGFR and KRAS hotspot regions.

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Authors and Affiliations

  1. Department of Molecular Medicine, Unit of Pathology, University of Pavia, and Foundation IRCCS Policlinico San Matteo, Via Forlanini 16, 27100, Pavia, Italy

    Sergio Carnevale, Giuseppina Ferrario & Patrizia Morbini

  2. PhD in Experimental Medicine, University of Pavia, Corso di Strada Nuova, 27100, Pavia, Italy

    Giuseppina Ferrario

  3. Department of Otorhinolaryngology, University of Pavia, and Foundation IRCCS Policlinico San Matteo, P.le Golgi 5, 27100, Pavia, Italy

    Fabio Sovardi & Marco Benazzo

Authors
  1. Sergio Carnevale
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  2. Giuseppina Ferrario
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  3. Fabio Sovardi
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  4. Marco Benazzo
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  5. Patrizia Morbini
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Correspondence to Patrizia Morbini.

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Carnevale, S., Ferrario, G., Sovardi, F. et al. Low-Grade Papillary Schneiderian Carcinoma: Report of a Case with Molecular Characterization. Head and Neck Pathol 14, 799–802 (2020). https://doi.org/10.1007/s12105-019-01067-5

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  • DOI: https://doi.org/10.1007/s12105-019-01067-5

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