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Fibrosing Interstitial Lung Disease in Children: An HRCT-Based Analysis

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Indian Journal of Pediatrics Aims and scope Submit manuscript

Abstract

Objective

To determine high resolution CT (HRCT) patterns of pulmonary fibrosis (PF) in children; and their etiological correlates.

Methods

This was a retrospective study involving 149 children with diffuse lung disease (DLD). Patterns of involvement were classified based on dominant lung finding as ground glass opacity (GGO) dominant, nodule dominant, cystic lung disease, or PF.

Patterns of PF were classified based on distribution and morphology into airway centric fibrosis (ACF), subpleural fibrosis (SPF), progressive massive fibrosis (PMF) and fibrocavitary. A comparison was made between the two dominant groups for apicobasal distribution, associated findings (GGO, nodules, cysts), and pulmonary artery hypertension (PAH).

Results

Nineteen patients showed PF on HRCT. ACF was commonest (52.6%), followed by SPF (42.1%). The common etiology was sarcoidosis (30%) in ACF, and connective tissue disorders (CTD) (50%) in SPF. Significant difference was found between ACF and SPF in apicobasal distribution (p = 0.04), presence of nodules (p = 0.03), and cysts (p = 0.02).

Conclusion

PF may present as an end stage of several childhood lung diseases. PF on imaging has discernible morphological patterns that correlate with underlying etiology.

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Authors and Affiliations

  1. Department of Radiodiagnosis and Interventional Radiology, All India Institute of Medical Sciences, New Delhi, 110029, India

    Deeksha Bhalla, Manisha Jana, Priyanka Naranje & Ashu Seith Bhalla

  2. Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India

    Sushil K. Kabra

Authors
  1. Deeksha Bhalla
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  2. Manisha Jana
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  3. Priyanka Naranje
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  4. Ashu Seith Bhalla
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  5. Sushil K. Kabra
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Contributions

DB, MJ, and PN conceived of the presented idea. MJ verified the analytical methods. ASB encouraged DB to investigate a specific aspect and supervised the findings of this work. All authors discussed the results and contributed to the final manuscript. SKK supervised the project. MJ will act as the guarantor for this paper.

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Correspondence to Manisha Jana.

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Bhalla, D., Jana, M., Naranje, P. et al. Fibrosing Interstitial Lung Disease in Children: An HRCT-Based Analysis. Indian J Pediatr 90, 153–159 (2023). https://doi.org/10.1007/s12098-021-04004-z

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  • DOI: https://doi.org/10.1007/s12098-021-04004-z

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