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Epidemiology and Genotype Distribution of Rotavirus Gastroenteritis in Under-Five Children of South Rajasthan, India

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Abstract

Objective

To determine the epidemiology of rotavirus diarrhea and its genotypes distribution among under five children from Udaipur, Rajasthan.

Methods

Hospital-based prospective study among children aged 0–59 mo of age hospitalized due to acute gastroenteritis and assess the clinical and epidemiological profile. Stool samples collected during 2017–2019 from 734 children, were tested by enzyme immune assay (EIA) to identify rotavirus and the samples that were positive were subjected to genotyping using published methods.

Results

Rotavirus was detected in 12.94% (95/734) of the stool samples. Maximum positivity (38.9%) was seen in children aged 12–23 mo followed by 34.7% in 6–11 mo of age. Detection rates were higher (46.31%, 44/95) during winter months of December–February; 65% children with rotavirus diarrhea had severe dehydration followed by moderate dehydration in 32% of cases. G3P[8] (40, 43.01%) was the commonest genotype followed by G9P[4] (10, 10.75%).

Conclusion

Among under-five children hospitalized due to acute gastroenteritis in a tertiary care setting in Udaipur, Rajasthan, 12.9% of children were rotavirus positive with predominant (43.01%) circulation of G3P[8] strains.

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Acknowledgements

The study was supported by the Indian Council of Medical Research, New Delhi; Ministry of Health and Family Welfare, Govt. of India and the State government of the participating institution.

The authors thank the team at Christian Medical College, Vellore for support, and the children and families for participation.

Funding

This work was supported by grants from the Bill and Melinda Gates Foundation to the Centers for Disease Control and Prevention, Atlanta, GA, USA (subcontract to Christian Medical College, Vellore grant no MOA#871-15SC) and the Translational Health Science and Technology Institute (grant no OPP1165083).

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Authors and Affiliations

  1. Department of Pediatrics, RNT Medical College, Udaipur, Rajasthan, 313001, India

    Bhupesh Jain, Suresh Goyal, Lakhan Poswal & Rekha Dangi

  2. The Wellcome Trust Research Laboratory, Christian Medical College (CMC), Vellore, Tamil Nadu, India

    Nayana P. Nair & Varunkumar Thiyagarajan

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  1. Bhupesh Jain
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Contributions

BJ reviewed literature, and prepared initial draft of manuscript; SG and LP conceptualized and designed the study and developed protocol; RD and BJ enrolled patients and collected data. NPN, VT and BJ analyzed the data. All authors had critically revised and approved the manuscript. SG will act as guarantor for this paper.

Corresponding author

Correspondence to Bhupesh Jain.

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The study was approved by the Institute Ethics Committee of RNT Medical College.

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Jain, B., Goyal, S., Poswal, L. et al. Epidemiology and Genotype Distribution of Rotavirus Gastroenteritis in Under-Five Children of South Rajasthan, India. Indian J Pediatr 88 (Suppl 1), 105–111 (2021). https://doi.org/10.1007/s12098-020-03626-z

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