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Complex roles of discoidin domain receptor tyrosine kinases in cancer

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Abstract

Discoidin domain receptors, DDR1 and DDR2 are members of the receptor tyrosine kinase (RTK) family that serves as a non-integrin collagen receptor and were initially identified as critical regulators of embryonic development and cellular homeostasis. In recent years, numerous studies have focused on the role of these receptors in disease development, in particular, cancer where they have been reported to augment ECM remodeling, invasion, drug resistance to facilitate tumor progression and metastasis. Interestingly, accumulating evidence also suggests that DDRs promote apoptosis and suppress tumor progression in various human cancers due to which their functions in cancer remain ill-defined and presents a case of an interesting therapeutic target. The present review has discussed the role of DDRs in tumorigenesis and the metastasis.

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Acknowledgements

This work in part was supported by an extramural research grant [EMR/2015/000761] to HC by the Department of Science and Technology-Science and Engineering Research Board (DST-SERB), Government of India. VM is grateful to ICMR, New Delhi, India for providing him the fellowship (No.3/1/3/JRF-2016/HRD). All the authors are thankful to the Central University of Punjab, Bathinda, India for additional support.

Funding

This study was funded by the Department of Science and Technology-Science and Engineering Research Board (DST-SERB), Government of India (EMR/2015/000761).

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  1. Department of Human Genetics and Molecular Medicine, Central University of Punjab, Bathinda, 151001, India

    V. Mehta, H. Chander & A. Munshi

  2. National Institute of Biologicals, Sector 62, Noida-201309, India

    H. Chander

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Mehta, V., Chander, H. & Munshi, A. Complex roles of discoidin domain receptor tyrosine kinases in cancer. Clin Transl Oncol 23, 1497–1510 (2021). https://doi.org/10.1007/s12094-021-02552-6

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