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Association of polymorphisms of CYP11B2 gene –344C/T and ACE gene I/D with antihypertensive response to angiotensin receptor blockers in Chinese with hypertension

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Abstract

The aim of this study was to determine whether the polymorphism of aldosterone synthase (CYP11B2) –344C/T and angiotensin-converting enzyme (ACE) insertion/deletion (I/D) were associated with the response of blood pressure (BP) to telmisartan treatment. After a two-week single-blind placebo run-in period, 148 patients with mild-to-moderate primary hypertension received monotherapy of telmisartan with 80 mg/day and then were followed up for eight weeks. Polymorphisms of CYP11B2 –344C/T and ACE I/D gene were determined through polymerase chain reaction-restriction fragment polymorphism analysis. The relationship between these polymorphisms and changes in BP was monitored and evaluated after eight weeks of treatment. With respect to the polymorphism of CYP11B2 –344C/T, the reduction in diastolic BP was significantly greater in patients carrying the C allele (CC+CT) compared with those carrying the TT genotype. There was no significant differences between ACE I/D polymorphism and BP reduction after treatment. We concluded that the aldosterone synthase –344C/T polymorphism was related to the antihypertensive treatment with telmisartan in hypertensive patients.

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Acknowledgement

Research supported by the Sino-German Laboratory for Molecular Medicine, FuWai Cardiovascular Hospital and Cardiovascular Institute, China.

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Authors and Affiliations

  1. Department of Cardiology, Beijing Tiantan Hospital, Capital University of Medical Science, Beijing, People’s Republic of China

    Hongtao Gong, Liying Mu, Tong Zhang, Xiuying Xu & Fenghe Du

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  1. Hongtao Gong
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  2. Liying Mu
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  3. Tong Zhang
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  4. Xiuying Xu
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  5. Fenghe Du
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Correspondence to Hongtao Gong.

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Corresponding editor: H. A. Ranganath

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Gong, H., Mu, L., Zhang, T. et al. Association of polymorphisms of CYP11B2 gene –344C/T and ACE gene I/D with antihypertensive response to angiotensin receptor blockers in Chinese with hypertension. J Genet 98, 1 (2019). https://doi.org/10.1007/s12041-018-1053-2

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