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Cu(II) complexes of 2-indole thiocarbohydrazones: synthesis, characterization and DNA cleavage studies

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Abstract

Two Schiff base ligands FT1 and FT2 and their Cu(II) complexes were synthesized and characterized by 1H NMR, ESI-MS, IR, UV-Visible, Fluorescence spectroscopy, EPR and single-crystal X-ray diffraction studies. FT1 crystallizes in the triclinic system while FT2 in the orthorhombic. The DNA cleavage activity of Cu(II) complexes was studied using plasmid pBR322 DNA by gel electrophoresis. All compounds cleave DNA on photoirradiation by oxidative mechanism.

Graphic abstract

Two Schiff base ligands FT1 and FT2 and their Cu(II) complexes were synthesized and characterized by 1H NMR, ESI-MS, IR, UV-Visible, Fluorescence spectroscopy, EPR and single-crystal X-ray diffraction studies. Both the Cu(II) complexes of indole thiocarbohydrazones are shown to cleave plasmid pBR322 DNA by oxidative mechanism.

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Acknowledgements

Financial support to SSP from Dr. Babasaheb Ambedkar National Research Fellowships (BANRF), Maharashtra, India, and Savitribai Phule Pune University (SPPU) is gratefully acknowledged. The Central Instrumentation Facility (CIF) of Savitribai Phule Pune University is acknowledged for single-crystal X-ray structures and ESI HR-MS. We also acknowledge the Sophisticated Analytical Instrumentation Facility (SAIF) at the Indian Institute of Technology Bombay, Mumbai for EPR measurements. Kind assistance in magnetic susceptibility measurements by Prof. Jayesh Gujarathi, Pratap College, Amalner is gratefully acknowledged.

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Authors and Affiliations

  1. Department of Chemistry, Savitribai Phule Pune University, Pune, 411007, India

    Shridhar Pawar, Anita Amate, Debamitra Chakravarty & Anupa A Kumbhar

  2. Department of Chemistry, Howard University, 2400 Sixth Street NW, Washington, DC, 20059, USA

    Raymond J Butcher

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  1. Shridhar Pawar
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  2. Anita Amate
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  3. Debamitra Chakravarty
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  5. Anupa A Kumbhar
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Correspondence to Anupa A Kumbhar.

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Special Issue on Beyond Classical Chemistry

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Pawar, S., Amate, A., Chakravarty, D. et al. Cu(II) complexes of 2-indole thiocarbohydrazones: synthesis, characterization and DNA cleavage studies. J Chem Sci 133, 107 (2021). https://doi.org/10.1007/s12039-021-01962-x

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  • DOI: https://doi.org/10.1007/s12039-021-01962-x

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