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Protein-rich extract of Musca domestica larvae alleviated metabolic disorder in STZ-induced type 2 diabetic rat model via hepatoprotective and pancreatic β-cell protective activities

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A Correction to this article was published on 24 October 2019

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Abstract

The study was designed to explore the beneficial effect of Musca domestica larvae extract (MDLE) on a metabolic disorder using a diabetic rat model. Streptozotocin-induced diabetic rats were treated with or without MDLE. Blood glucose, insulin levels, lipid profiles, and oxidative stress markers were measured. The morphological changes in the pancreas and liver were determined, as well as insulin expression. The expression of glucose transporter 4 (GLUT4), phospho-adenosine monophosphate-activated protein kinase (p-AMPK)/total AMPK, superoxide dismutase 1 (SOD1), catalase (CAT), and peroxisome proliferator-activated receptor gamma (PPARγ) were detected. Compared with untreated diabetic rats, MDLE-treated rats had decreased urine volume, food intake, and water intake, along with significantly lower levels of blood glucose, malondialdehyde (MDA), plasma triglycerides, low-density lipoprotein (LDL), and total cholesterol. MDLE-treated rats also had higher levels of SOD activity, high-density lipoprotein (HDL), and insulin. MDLE treatment partially restored the β-cell population, improved the liver necrosis and islet cell damage, reversed the decreased expression of GLUT4, phospho-AMPK, SOD1, and CAT in the liver, skeletal muscle and pancreatic tissue, and also increased the expression of PPARγ in the liver and adipose tissue in diabetic rats. In conclusion, the obtained results suggest that MDLE could possibly be used pharmacologically as an adjuvant for the treatment of diabetes.

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Change history

  • 24 October 2019

    In the December 2018 issue of the Journal of Biosciences, in the article titled ‘‘Protein-rich extract of Musca domestica larvae alleviated metabolic disorder in STZ-induced type 2 diabetic rat model via hepatoprotective and pancreatic β -cell protective activities’’ by Hanfang Mei et al. (DOI: 10.1007/s12038-018-9804-z; Vol. 43, No. 5, pp. 969–983), the affiliations of Hanfang Mei have been incompletely mentioned as:

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Acknowledgements

The present study was supported by grants from the National Natural Science Foundation of China (NSFC, 81401150; NSFC, 81403129); and the Science and Technology Cooperation Research Project of Chinese Medicinal Medicine Industry, Jianhe, Guizhou, China (Bureau of Science and Technology of Jianhe County No. 5).

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    Authors and Affiliations

    1. Guangdong Key Laboratory of Pharmaceutical Bioactive Substances, Guangzhou, 510006, Guangdong, China

      Hanfang Mei, Wenbin Liu & Jiayong Zhu

    2. School of Basic Courses, Guangzhou, 510006, Guangdong, China

      Hanfang Mei, Yinru He, Xia Yang, Wenbin Liu & Wei Tian

    3. Department of Biochemistry and Molecular Biology, Guangdong Pharmaceutical University, Guangzhou Higher Education Mega Center, Guangzhou, 510006, Guangdong, China

      Hanfang Mei

    4. Department of Laboratory Science, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510120, Guangdong, China

      Jianhua Xu

    5. Key Laboratory of Digital Quality Evaluation of Chinese Material Medica of ASTCM, Guangdong Pharmaceutical University, Guangzhou Higher Education Mega Center, Guangzhou, 510006, Guangdong, China

      Yu Zeng

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    1. Hanfang Mei
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    Correspondence to Yu Zeng or Jiayong Zhu.

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    Communicated by Ullas Kolthur-Seetharam.

    Corresponding editor: Ullas Kolthur-Seetharam

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    Mei, H., Xu, J., He, Y. et al. Protein-rich extract of Musca domestica larvae alleviated metabolic disorder in STZ-induced type 2 diabetic rat model via hepatoprotective and pancreatic β-cell protective activities. J Biosci 43, 969–983 (2018). https://doi.org/10.1007/s12038-018-9804-z

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