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Microbiota Metabolites and Immune Regulation Affect Ischemic Stroke Occurrence, Development, and Prognosis

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Abstract

The gut microbiota are not only related to the development and occurrence of digestive system disease, but also have a bidirectional relationship with nervous system diseases via the microbiota-gut-brain axis. At present, correlations between the gut microbiota and neurological diseases, including stroke, are one of the focuses of investigation and attention in the medical community. Ischemic stroke (IS) is a cerebrovascular disease accompanied by focal neurological deficit or central nervous system injury or death. In this review, we summarize the contemporary latest research on correlations between the gut microbiota and IS. Additionally, we discuss the mechanisms of gut microbiota implicated in IS and related to metabolite production and immune regulation. Moreover, the factors of gut microbiota that affecting IS occurrence, and research implicating the gut microbiota as potential therapeutic targets for IS, are highlighted. Our review highlights the evidential relationships and connections between the gut microbiota and IS pathogenesis and prognosis.

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Data Availability

The datasets generated during and/or analyzed during the current study are available in the Pubmed repository, https://pubmed.ncbi.nlm.nih.gov/.

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Funding

This research was supported financially by the Sichuan Science and Technology Program (2023NSFSC1698, 2022NSFSC1539, 2023NSFSC0529, and 2022YFS0629), Technology Strategic Cooperation Project of Luzhou Municipal People’s Government–Southwest Medical University (2018LZNYD-ZK26), and the Foundation of Southwest Medical University (2022QN042, 2022QN085, 2022QN102, and 2022QN118).

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Authors and Affiliations

  1. The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, China

    Tao Wang, Chuanling Pan, Cheng Xie, Liying Chen & Huiling Liao

  2. Southwest Medical University, 646000, Luzhou, People’s Republic of China

    Zhangyong Song & Caiyan Xin

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  1. Tao Wang
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  2. Chuanling Pan
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  3. Cheng Xie
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  4. Liying Chen
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  5. Zhangyong Song
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  6. Huiling Liao
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  7. Caiyan Xin
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All authors contributed to the study conception and design. The first draft of the manuscript was written by Tao Wang and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Huiling Liao or Caiyan Xin.

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Wang, T., Pan, C., Xie, C. et al. Microbiota Metabolites and Immune Regulation Affect Ischemic Stroke Occurrence, Development, and Prognosis. Mol Neurobiol 60, 6176–6187 (2023). https://doi.org/10.1007/s12035-023-03473-x

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