Abstract
Neurodegenerative diseases (NDs), including chronic disease such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and multiple sclerosis, and acute diseases like traumatic brain injury and ischemic stroke are characterized by progressive degeneration, brain tissue damage and loss of neurons, accompanied by behavioral and cognitive dysfunctions. So far, there are no complete cures for NDs; thus, early and timely diagnoses are essential and beneficial to patients’ treatment. Magnetic resonance imaging (MRI) has become one of the advanced medical imaging techniques widely used in the clinical examination of NDs due to its non-invasive diagnostic value. In this review, research published in English in current decade from PubMed electronic database on the use of MRI to detect specific biomarkers of NDs was collected, summarized, and discussed, which provides valuable suggestions for the early diagnosis, prevention, and treatment of NDs in the clinic.
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References
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The authors would like to express their gratitude to EditSprings (https://www.editsprings.cn/) for the expert linguistic services provided.
Funding
This work was supported by Grants from the National Natural Science Foundation of China (Grant No. 81903829), the Joint project of Luzhou Municipal People’s Government and Southwest Medical University, China (Grant No. 2018LZXNYD-ZK42).
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K-RL and LY conceived the idea. C-LY, YT, and J-MW completed the work of literature retrieval. K-RL, LY, and X-PH provided written input on scientific content of drafts. G-QH, A-GW, and LY revised the manuscript and approved the final draft for submission. All authors approved the final version of the manuscript.
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Highlights
1. We summarized various types of biomarkers in NDs with MRI detection including pathogenic proteins, anatomical structures, body materials and pathological conditions.
2. Most biomarkers we listed are specific to different NDs which can be manifested by magnetic resonance.
3. We discussed the possibility that other biomarkers such as Aβ and p-Tau which could also be used for non-invasive examination by magnetic resonance in the future.
4. These biomarkers reveal the profound pathological features of NDs, which provide evidence for preclinical and clinical studies.
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Li, KR., Wu, AG., Tang, Y. et al. The Key Role of Magnetic Resonance Imaging in the Detection of Neurodegenerative Diseases-Associated Biomarkers: A Review. Mol Neurobiol 59, 5935–5954 (2022). https://doi.org/10.1007/s12035-022-02944-x
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DOI: https://doi.org/10.1007/s12035-022-02944-x