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Cyclins, Cyclin-Dependent Kinases, and Cyclin-Dependent Kinase Inhibitors in the Mouse Nervous System

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Abstract

Development and normal physiology of the nervous system require proliferation and differentiation of stem and progenitor cells in a strictly controlled manner. The number of cells generated depends on the type of cell division, the cell cycle length, and the fraction of cells that exit the cell cycle to become quiescent or differentiate. The underlying processes are tightly controlled and modulated by cyclin-dependent kinases (Cdks) and their interactions with cyclins and Cdk inhibitors (CKIs). Studies performed in the nervous system with mouse models lacking individual Cdks, cyclins, and CKIs, or combinations thereof, have shown that many of these molecules control proliferation rates in a cell-type specific and time-dependent manner. In this review, we will provide an update on the in vivo studies on cyclins, Cdks, and CKIs in neuronal and glial tissue. The goal is to highlight their impact on proliferation processes during the development of the peripheral and central nervous system, including and comparing normal and pathological conditions in the adult.

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Acknowledgments

We thank Dr. Ned Mantei for comments on the manuscript.

Funding

A. G. was supported by the University of Basel Research Fund for excellent early career researchers. S. A. was supported by the Swiss National Science Foundation and the Swiss Federal Government (SystemsX.ch The Swiss Initiative in Systems Biology).

Author information

Authors and Affiliations

  1. Department of Biomedicine, University of Basel, Basel, Switzerland

    Alice Grison & Suzana Atanasoski

  2. Faculty of Medicine, University of Zurich, Zurich, Switzerland

    Suzana Atanasoski

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  1. Alice Grison
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  2. Suzana Atanasoski
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Correspondence to Suzana Atanasoski.

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Grison, A., Atanasoski, S. Cyclins, Cyclin-Dependent Kinases, and Cyclin-Dependent Kinase Inhibitors in the Mouse Nervous System. Mol Neurobiol 57, 3206–3218 (2020). https://doi.org/10.1007/s12035-020-01958-7

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