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Role of GTPases in the Regulation of Mitochondrial Dynamics in Alzheimer’s Disease and CNS-Related Disorders

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Abstract

Data obtained from several studies have shown that mitochondria are involved and play a central role in the progression of several distinct pathological conditions. Morphological alterations and disruptions on the functionality of mitochondria may be related to metabolic and energy deficiency in neurons in a neurodegenerative disorder. Several recent studies demonstrate the linkage between neurodegeneration and mitochondrial dynamics in the spectrum of a promising era called precision mitochondrial medicine. In this review paper, an analysis of the correlation between mitochondria, Alzheimer’s disease, and other central nervous system (CNS)-related disorders like the Parkinson’s disease and the autism spectrum disorder is under discussion. The role of GTPases like the mfn1, mfn2, opa1, and dlp1 in mitochondrial fission and fusion is also under investigation, influencing mitochondrial population and leading to oxidative stress and neuronal damage.

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Authors and Affiliations

  1. Novel Global Community Educational Foundation, Hebersham, Australia

    Athanasios Alexiou & Mohammad Amjad Kamal

  2. AFNP Med Austria, Haidingergasse 29, 1030, Wien, Austria

    Athanasios Alexiou & Stylianos Chatzichronis

  3. Medical School, Bioinformatics Program, University of Crete, Heraklion, Greece

    Georgia Soursou

  4. Department of Informatics and Telecommunications, Bioinformatics Program, National and Kapodistrian University of Athens, Athens, Greece

    Stylianos Chatzichronis

  5. Department of Psychology, City Unity College of Athens, Athens, Greece

    Ermis Gasparatos

  6. King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia

    Mohammad Amjad Kamal & Ghulam Md Ashraf

  7. Enzymoics, 7 Peterlee Place, Hebersham, NSW, 2770, Australia

    Mohammad Amjad Kamal

  8. Department of Biochemistry and Bioinformatics, Institute of Science, GITAM University, Visakhapatnam, Andhra Pradesh, 530045, India

    Nagendra Sastry Yarla

  9. School of Life Sciences, Glocal University, Mirzapur Pole, Saharanpur, Uttar Pradesh, India

    Asma Perveen

  10. Departamento de Nutrición y Bioquímica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá, DC, Colombia

    George E. Barreto

  11. Instituto de Ciencias Biomédicas, Universidad Autónoma de Chile, Santiago, Chile

    George E. Barreto

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  1. Athanasios Alexiou
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  2. Georgia Soursou
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  4. Ermis Gasparatos
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Correspondence to Athanasios Alexiou, George E. Barreto or Ghulam Md Ashraf.

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Alexiou, A., Soursou, G., Chatzichronis, S. et al. Role of GTPases in the Regulation of Mitochondrial Dynamics in Alzheimer’s Disease and CNS-Related Disorders. Mol Neurobiol 56, 4530–4538 (2019). https://doi.org/10.1007/s12035-018-1397-x

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  • DOI: https://doi.org/10.1007/s12035-018-1397-x

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