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Effect of Gestational Exposure of Cypermethrin on Postnatal Development of Brain Cytochrome P450 2D1 and 3A1 and Neurotransmitter Receptors

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A Correction to this article was published on 02 September 2019

An Erratum to this article was published on 30 October 2014

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Abstract

Oral administration of low doses (1.25, 2.5, or 5 mg/kg) of cypermethrin to pregnant Wistar rats from gestation days 5 to 21 led to dose-dependent differences in the induction of cytochrome P450 2D1 (CYP2D1) and 3A1 messenger RNA (mRNA) and protein in brain regions isolated from the offsprings postnatally at 3 weeks that persisted up to adulthood (12 weeks). Similar alterations were observed in the expression of GABAergic, muscarinic, dopaminergic, and serotonergic neurotransmitter receptors in brain regions of rat offsprings. Rechallenge of the prenatally exposed offsprings at adulthood (12 weeks old) with cypermethrin (p.o., 10 mg/kg for 6 days) led to a greater magnitude of alterations in the expression of CYPs, neurotransmitter receptors, and neurotransmitter receptor binding in the brain regions when compared to the control offsprings treated at adulthood with cypermethrin or prenatally exposed offsprings. A greater magnitude of decrease was also observed in the spontaneous locomotor activity (SLA) in prenatally exposed offsprings rechallenged with cypermethrin. The present data indicating similarities in the alterations in the expression of CYPs (2D1 and 3A1) and neurotransmitter receptors in brain has led us to suggest that endogenous function regulating CYPs is possibly associated with neurotransmission processes. A greater magnitude of alterations in CYP2D1, 3A1, neurotransmitter receptors, and SLA in rechallenged animals has further provided evidence that alterations in CYPs are possibly linked with neurotransmission processes.

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Change history

  • 30 October 2014

    An erratum to this article has been published.

  • 02 September 2019

    The original version of this article unfortunately contained errors in Fig.��4a. Representative image of b-actin of brain region were copied incorrectly during the preparation of the figures.

  • 02 September 2019

    The original version of this article unfortunately contained errors in Fig.��4a. Representative image of b-actin of brain region were copied incorrectly during the preparation of the figures.

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Acknowledgments

The authors are grateful to the Director, CSIR—Indian Institute of Toxicology Research, Lucknow, for his keen interest and support in carrying out the study. AS is thankful to CSIR, N. Delhi for providing Senior Research Fellowship. The financial assistance of the Department of Biotechnology, N. Delhi is also gratefully acknowledged.

Conflict of Interest

The authors declare that they have no competing financial interests.

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Authors and Affiliations

  1. Developmental Toxicology Division, CSIR—Indian Institute of Toxicology Research, Post Box No. 80, M.G. Marg, Lucknow, 226001, Uttar Pradesh, India

    Anshuman Singh, Anubha Mudawal, Rajendra K. Shukla, Sanjay Yadav, Vinay K Khanna & Devendra Parmar

  2. School of Bio Sciences and Technology, Vellore Institute of Technology, Vellore, 632014, Tamil Nadu, India

    Anshuman Singh & Rao Sethumadhavan

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  1. Anshuman Singh
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Correspondence to Devendra Parmar.

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An erratum to this article is available at https://doi.org/10.1007/s12035-014-8960-x.

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Singh, A., Mudawal, A., Shukla, R.K. et al. Effect of Gestational Exposure of Cypermethrin on Postnatal Development of Brain Cytochrome P450 2D1 and 3A1 and Neurotransmitter Receptors. Mol Neurobiol 52, 741–756 (2015). https://doi.org/10.1007/s12035-014-8903-6

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