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Expression of MTA1 in nasopharyngeal carcinoma and its correlation with prognosis

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Abstract

Metastasis-associated protein 1 (MTA1) is related to tumour metastasis and poor prognosis in various human cancers. The aim of this study was to investigate the expression of MTA1 in nasopharyngeal carcinoma (NPC) and explore the prognostic value of MTA1 in NPC patients. The expression of MTA1 in 136 human NPC tissues and 20 normal nasopharyngeal tissues was detected using immunohistochemistry, quantified and classified into low or high expression using a 50 % cut-off level. The relationships of MTA1 expression with the clinical characteristics and survival of patients were analysed. MTA1-positive staining was observed in the nuclei of NPC cells, and MTA1 expression was significantly correlated with T stage (P = 0.006), clinical stage (P = 0.001) and distant metastasis (P < 0.001). Patients with high MTA1 expression exhibited significantly worse distant metastasis-free survival (DMFS) than those with low MTA1 expression (90.75 % vs. 70.81 %, P =  0.017). Multivariate survival analysis revealed that MTA1 expression was an independent prognostic factor for DMFS (P = 0.038). In this study, high MTA1 expression was significantly associated with poor DMFS in NPC, indicating that MTA1 could serve as a novel biomarker for assessing the metastatic potential of NPC and could act as a possible therapeutic target for the treatment of metastatic nasopharyngeal carcinoma.

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Acknowledgments

We are grateful to Mrs. Wei-Ying Gao of the Department of Clinical Pathology for performing the tissue immunostaining and to Mrs. Zhi-Juan Pan of the Department of Information, who provided the follow-up data. This research was supported by the Health Department of Guangdong Province (Grant Number B2013185) and by a major special fund of the Affiliated Cancer Hospital of Guangzhou Medical University.

Conflict of interest

The authors declare that they have no conflicts of interest.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Ethical standard

This study has been approved by the Ethics Committee of our hospital and has therefore been performed in accordance with the ethical standards described in the 1964 Declaration of Helsinki and its subsequent amendments.

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Authors and Affiliations

  1. Department of Radiotherapy, Affiliated Cancer Hospital of Guangzhou Medical University, No. 78, Hengzhigang Road, Yuexiu District, Guangzhou, 510095, Guangdong, China

    Taize Yuan, Huanhuan Zhang, Yin Liang, Ronghui Zheng, Jin Deng & Xiuping Zhang

  2. Department of Medical Oncology, Cancer Center of Sun Yat-sen University, Guangzhou, 510060, Guangdong, China

    Baoqiong Liu

  3. Department of Pathology, Affiliated Cancer Hospital of Guangzhou Medical University, Guangzhou, 510095, Guangdong, China

    Qiong Zhang

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  1. Taize Yuan
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  2. Huanhuan Zhang
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  4. Qiong Zhang
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  6. Ronghui Zheng
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  7. Jin Deng
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Corresponding author

Correspondence to Xiuping Zhang.

Additional information

Taize Yuan and Huanhuan Zhang have contributed equally to this study and should be considered co-first authors.

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Yuan, T., Zhang, H., Liu, B. et al. Expression of MTA1 in nasopharyngeal carcinoma and its correlation with prognosis. Med Oncol 31, 330 (2014). https://doi.org/10.1007/s12032-014-0330-z

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  • DOI: https://doi.org/10.1007/s12032-014-0330-z

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