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Investigation of DNA repair gene variants on myelodysplastic syndromes in a Turkish population

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Abstract

The aim of this study was to assess the possible influence of genetic polymorphisms in hOGG1, XRCC1, XRCC3, XPD, XPG and APE1 on the observed DNA damage in a group of Turkish myelodysplastic syndrome (MDS) patients. A total of 39 patients with myelodysplastic syndrome and 78 age-matched healthy control subjects were included in our study. Polymerase chain reaction/restriction fragment length polymorphism analysis was performed for the detection of DNA repair gene variants. No significant differences in DNA repair enzymes APE1, XRCC1 and XPG were found between MDS patients and controls. On the other hand, XRCC3, XPD and hOGG1 were associated with an increased risk of MDS (p = 0.004, p = 0.000, p = 0.017, respectively). Specifically, Thr/Met genotype was more relevant in patients (p = 0.026) in XRCC3; in hOGG1, Cys+ genotype was found higher in patients (p = 0.017); and in XPD, Gln/Gln genotypes were found higher in the patient (p = 0.001). In conclusion, XRCC3, XPD and hOGG1 genotypes are associated with an increased MDS risk, suggesting their possible involvement in the pathogenesis and biology of this disease.

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Acknowledgments

Istanbul Haseki Training and Research Hospital financially supported the study.

Conflict of interests

The authors declare no competing interest.

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Authors and Affiliations

  1. Department of Internal Medicine, Istanbul Haseki Training and Research Hospital, Istanbul, Turkey

    Mehmet Burak Aktuglu, Mesut Ayer, Hasan Acik, Zeynep Karaali, Taner Alioglu, Namik Yigit & Mustafa Velet

  2. Department of Molecular Medicine, Institute for Experimental Medicine Research (DETAE), Istanbul University, Istanbul, Turkey

    Elif S. Bireller, Cagla Rencuzogullari & Bedia Cakmakoglu

  3. Department of Internal Medicine, Kars Kafkas University Medical Faculty, Kars, Turkey

    Eray Atalay

  4. Department of Internal Medicine, Istanbul Bagcilar Training and Research Hospital, Istanbul, Turkey

    Oznur Sari Ure

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  1. Mehmet Burak Aktuglu
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  2. Mesut Ayer
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  3. Elif S. Bireller
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  4. Cagla Rencuzogullari
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  12. Bedia Cakmakoglu
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Correspondence to Mehmet Burak Aktuglu.

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Aktuglu, M.B., Ayer, M., Bireller, E.S. et al. Investigation of DNA repair gene variants on myelodysplastic syndromes in a Turkish population. Med Oncol 31, 174 (2014). https://doi.org/10.1007/s12032-014-0174-6

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  • DOI: https://doi.org/10.1007/s12032-014-0174-6

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