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Outcome Following Percutaneous Transhepatic Biliary Drainage (PTBD) in Carcinoma Gallbladder: a Prospective Observational Study

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Abstract

Introduction

Percutaneous biliary drainage (PTBD) is required as palliation and optimization for surgery or chemotherapy in carcinoma gallbladder (GBC) but may be associated with complications. We aimed to study the outcomes, complications, and changes in quality of life in patients with GBC undergoing PTBD.

Methods

A prospective study from July 2018 to December 2019 in patients of GBC presenting with obstructive jaundice was done. Patients planned for PTBD were included in the study. The progression of the disease, complications of PTBD, reinterventions, effects on initiation or completion of chemotherapy, surgical resection or intervention, and overall survival were recorded. Quality of life (QoL) was assessed using the SF-36 questionnaire before and after 4–6 weeks of intervention.

Results

Of 160 patients assessed for inclusion, 60 (mean age 53.7 ± 10.95 years, 27 (45%) males) were eventually included. Eleven patients (18.3%) had metastatic disease at presentation. Of 60 patients undergoing PTBD, none had immediate procedure-related complications, 41 (68%) patients had at least one, and 18 (30%) patients had more than one complication. The most common complication was peri-catheter bile leak (41.6%), followed by catheter dislodgement (30%), blockage (23.3%), and bleeding (10%). Reintervention was required in 32 (53%) patients. There was a significant decrease in QoL after PTBD (P < 0.0001). Median survival after PTBD was 12 weeks.

Conclusion

The high technical success of PTBD does not translate into the improvement of QoL.

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Authors and Affiliations

  1. Department of General Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India

    Vanji Nathan Subramani & Hemanth Kumar

  2. Surgical Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, India

    Mohanasundaram Avudaiappan, Thakur Deen Yadav & Harjeet Singh

  3. Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, India

    Vishal Sharma & Harshal Mandavdhare

  4. Radiodiagnosis, Post Graduate Institute of Medical Education and Research, Chandigarh, India

    Ujjwal Gorsi

Authors
  1. Vanji Nathan Subramani
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  2. Mohanasundaram Avudaiappan
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  3. Thakur Deen Yadav
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  4. Hemanth Kumar
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  5. Vishal Sharma
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  6. Harshal Mandavdhare
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  7. Ujjwal Gorsi
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  8. Harjeet Singh
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Contributions

Study concept and design: HS, VNS. Data acquisition: HS, VNS, TDY, MA, HK, UG. Data analysis: HS, VNS, MA, VS, HM. Drafting the manuscript: HS, VNS, TDY, VS, HM. Supervision: HS, TDY, UG, HK.

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Correspondence to Harjeet Singh.

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Subramani, V.N., Avudaiappan, M., Yadav, T.D. et al. Outcome Following Percutaneous Transhepatic Biliary Drainage (PTBD) in Carcinoma Gallbladder: a Prospective Observational Study. J Gastrointest Canc 53, 543–548 (2022). https://doi.org/10.1007/s12029-021-00655-5

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  • DOI: https://doi.org/10.1007/s12029-021-00655-5

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