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Bronchiolitis obliterans organizing pneumonia in patients with autoimmune rheumatic diseases

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Abstract

Bronchiolitis obliterans organizing pneumonia (BOOP) is defined by buds of granulation tissue within lung distal airspaces. The diagnosis requires the histopathologic evidence of organizing pneumonia along with a suggestive clinical and radiographic pattern. This disorder is characterized by a good response to corticosteroids and an excellent prognosis. It can occur in association with a broad spectrum of clinical conditions or can be isolated, in this last case named cryptogenic organizing pneumonia. We searched for BOOP in patients with autoimmune rheumatic diseases (ARD) in the literature, and we found 32 well-documented cases. We reported here demographic features, manifestations, treatment and outcome of patients with BOOP associated with ARD. Notably, BOOP can be the presenting feature in some patients with ARD; thus, a close follow-up of patients with BOOP is recommended.

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Authors and Affiliations

  1. Internal Medicine Department, Biomedical Institute of Malaga (IBIMA), University Hospitals, Regional and Clinical Virgen de la Victoria of Malaga, Málaga, Spain

    Carmen Maria Lara Rojas, Enrique De Ramón & Ricardo Gomez-Huelgas

  2. Rheumatology Unit, Department of Medicine—DIMED, University of Padova, Via Giustiniani, 2, 35128, Padua, Italy

    Elisabetta Borella, Lavinia Palma, Leonardo Punzi & Andrea Doria

  3. Internal Medicine, University Hospital Salamanca, Salamanca, Spain

    Silvio Ragozzino

  4. Ciber Fisiopatología de la Obesidad y Nutrición (CB06/003), Instituto de Salud Carlos III, Madrid, Spain

    Ricardo Gomez-Huelgas

Authors
  1. Carmen Maria Lara Rojas
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  2. Elisabetta Borella
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  3. Lavinia Palma
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Correspondence to Andrea Doria.

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Rojas, C.M.L., Borella, E., Palma, L. et al. Bronchiolitis obliterans organizing pneumonia in patients with autoimmune rheumatic diseases. Immunol Res 61, 97–103 (2015). https://doi.org/10.1007/s12026-014-8607-z

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  • DOI: https://doi.org/10.1007/s12026-014-8607-z

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