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Hyperglycemia predicts adverse prognosis in advanced pancreatic cancer patients

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Abstract

Background

Diabetes mellitus is a prevalent comorbidity in pancreatic cancer. Previous studies have mainly concentrated on the association between diabetes and pancreatic cancer outcomes. However, research on the impact of hyperglycemia on the prognosis of patients with advanced pancreatic cancer is limited.

Methods

Information on patients with advanced pancreatic cancer was collected from a prospectively maintained database, and the patients were divided into the hyperglycemia group (fasting blood glucose ≥7.0 mmol/L) and the normoglycemia group (fasting blood glucose < 7.0 mmol/L). Patients with preexisting diabetes were not included in these groups. The associations between hyperglycemia and clinical variables or prognosis were analyzed.

Results

Among 697 patients with advanced pancreatic cancer and no prior history of diabetes, 25.3% were diagnosed with hyperglycemia. Patients older than 65 years had a higher risk of developing hyperglycemia (P = 0.044). Patients with hyperglycemia had a worse prognosis than those with normoglycemia (median survival, 7.5 vs. 8.8 months, P < 0.001). Hyperglycemia was associated with increased mortality (hazard ratio = 1.38; P = 0.003).

Conclusions

Hyperglycemia predicts worse overall survival in patients with advanced pancreatic cancer.

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Acknowledgements

We would like to thank American Journal Experts (www.aje.com) for English language editing.

Author contributions

All authors contributed to the study’s conception and design. G.L. and X.Y.: conceptualization and funding acquisition. Z.X., X.Z., and H.X.: resources and investigation and data curation. G.L. and X.Y.: project administration. G.L. and Q.N.: review and editing. Z.X., X.Z., and H.X.: formal analysis and software and writing—original draft. All authors read and approved the final paper.

Funding

This work was supported by the National Natural Science Foundation of China (82072693, 81625016, 81871940, 81902417, 82172625), the Scientific Innovation Project of Shanghai Education Committee (2019-01-07-00-07-E00057), Clinical and Scientific Innovation Project of Shanghai Hospital Development Center (SHDC12018109, SHDC2020CR1006A), the Shanghai Cancer Center Foundation for Distinguished Young Scholars (grant number YJJQ201803), Shanghai Charity Foundation (HYXH2021042), and the Fudan University Personalized Project for “Double Top” Original Research (grant number XM03190633).

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Authors and Affiliations

  1. Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200032, China

    Xinzhe Zhu, Huaxiang Xu, Zhiwen Xiao, He Liu, Quanxing Ni, Xianjun Yu & Guopei Luo

  2. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China

    Xinzhe Zhu, Huaxiang Xu, Zhiwen Xiao, He Liu, Quanxing Ni, Xianjun Yu & Guopei Luo

  3. Shanghai Pancreatic Cancer Institute, Shanghai, 200032, China

    Xinzhe Zhu, Huaxiang Xu, Zhiwen Xiao, He Liu, Quanxing Ni, Xianjun Yu & Guopei Luo

  4. Pancreatic Cancer Institute, Fudan University, Shanghai, 200032, China

    Xinzhe Zhu, Huaxiang Xu, Zhiwen Xiao, He Liu, Quanxing Ni, Xianjun Yu & Guopei Luo

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  1. Xinzhe Zhu
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These authors contributed equally: Xinzhe Zhu, Huaxiang Xu, Zhiwen Xiao

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Zhu, X., Xu, H., Xiao, Z. et al. Hyperglycemia predicts adverse prognosis in advanced pancreatic cancer patients. Endocrine 79, 296–303 (2023). https://doi.org/10.1007/s12020-022-03196-4

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