Abstract
One class of molecules that are now coming to be recognized as essential for our understanding of the nervous system are the lysophospholipids. One of the major signaling lysophospholipids is lysophosphatidic acid, also known as LPA. LPA activates a variety of G protein-coupled receptors (GPCRs) leading to a multitude of physiological responses. In this review, I describe our current understanding of the role of LPA and LPA receptor signaling in the development and function of the nervous system, especially the central nervous system (CNS). In addition, I highlight how aberrant LPA receptor signaling may underlie neuropathological conditions, with important clinical application.
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Acknowledgements
I would like to thank Allison Reed and Thomas Gonzalez from the Birgbauer laboratory for critical reading of this manuscript. E. B. was supported in part by Grant P20GM103499 (SC INBRE) from the National Institute of General Medical Sciences, National Institutes of Health.
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E.B. has been supported in part by Grant P20GM103499 (SC INBRE) from the National Institute of General Medical Sciences, National Institutes of Health.
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Birgbauer, E. Lysophosphatidic Acid Signalling in Nervous System Development and Function. Neuromol Med 23, 68–85 (2021). https://doi.org/10.1007/s12017-020-08630-2
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DOI: https://doi.org/10.1007/s12017-020-08630-2