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Cellular Heterogeneity Facilitates the Functional Differences Between Hair Follicle Dermal Sheath Cells and Dermal Papilla Cells: A New Classification System for Mesenchymal Cells within the Hair Follicle Niche

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Abstract

Mesenchymal stem cells (MSCs) are known for their self-renewal and multi-lineage differentiation potential, with these cells often being evaluated in the regulation and maintenance of specific cellular niches including those of the hair follicle. Most mesenchymal stem cells in the hair follicles are housed in the dermal papilla (DP) and dermal sheath (DS), with both niches characterized by a broad variety of cellular subsets. However, while most previous studies describing the hair follicle mesenchymal niche treated all DP and DS cells as Hair Follicle Mesenchymal Stem Cells (HF-MSCs), the high number of cellular subsets would suggest that these cells are actually too heterogenous for such a broad definition. Given this we designed this study to evaluate the differentiation processes in these cells and used this data to create a new set of classifications for DP and DS cells, dividing them into "hair follicle mesenchymal stem cells (HF-MSCs)", "hair follicle mesenchymal progenitor cells (HF-MPCs)", and "hair follicle mesenchymal functional cells (HF-MFCs)". In addition, those cells that possess self-renewal and differentiation were re-named hair follicle derived mesenchymal multipotent cells (HF-MMCs). This new classification may help to further our understanding of the heterogeneity of hair follicle dermal cells and provide new insights into their evaluation.

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Funding

This study was funded by the National Natural Science Foundation of China (Grant Nos. 81701929, 81772104, and 81971889), the Natural Science Foundation of Guangdong Province (Grant Nos.2019A1515012170, 2020A1515110037) and the Science and Technology Program of Guangzhou (Grant No. 201904010480).

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  1. Yuyang Gan and Hailin Wang contributed equally to this study.

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  1. Department of Plastic and Aesthetic Surgery, Nanfang Hospital Southern Medical University, 1838 Guangzhou North Road Guangzhou, Guangdong, People’s Republic of China

    Yuyang Gan, Hailin Wang, Lijuan Du, Kaitao Li, Qian Qu, Pingping Sun, Zhexiang Fan, Jin Wang, Ruosi Chen, Zhiqi Hu & Yong Miao

  2. Shanghai East Hospital of Tongji University, Shang Hai, China

    Weiwen Liu

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  1. Yuyang Gan
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This article belongs to the Topical Collection: Special Issue on Stem Cell Technology and Skin Disorders (Dermatology): from Stem Cell Biology to Clinical Application

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Gan, Y., Wang, H., Du, L. et al. Cellular Heterogeneity Facilitates the Functional Differences Between Hair Follicle Dermal Sheath Cells and Dermal Papilla Cells: A New Classification System for Mesenchymal Cells within the Hair Follicle Niche. Stem Cell Rev and Rep 18, 2016–2027 (2022). https://doi.org/10.1007/s12015-022-10411-2

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