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Heterogeneity of Human Mesenchymal Stromal/Stem Cells

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Stem Cells Heterogeneity - Novel Concepts

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1123))

Abstract

Increasing evidence has shown that mesenchymal stem cells (MSCs) isolated from body tissues are heterogeneous while being examined in vitro and in vivo. Besides some common characteristics, MSCs derived from different tissues exhibit unique biological properties. In addition, the therapeutic effects of MSCs may vary widely due to their heterogeneity and the technical differences in large-scale ex vivo expansion. In this chapter, the heterogeneity of MSCs will be discussed in three levels: the individual donors, the tissue sources, and the cell surface markers.

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Author information

Authors and Affiliations

  1. National Engineering Research Center of Cell Products, Tianjin AmCellGene Engineering Co., Ltd, Tianjin, China

    Weiqiang Wang & Zhong Chao Han

  2. Tianjin Institute of Health & Stem Cells, Health & Biotech Co., Ltd, Tianjin, China

    Weiqiang Wang & Zhong Chao Han

  3. Jiangxi Provincial Engineering Technology Research Center of Stem Cell, Jiangxi, China

    Weiqiang Wang & Zhong Chao Han

  4. Beijing Institute of Stem Cells, Health & Biotech Co., Ltd., Beijing, China

    Zhong Chao Han

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  1. Weiqiang Wang
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  2. Zhong Chao Han
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Editors and Affiliations

  1. Department of Radiology, Columbia University Medical Center, New York, NY, USA

    Alexander Birbrair

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Wang, W., Han, Z.C. (2019). Heterogeneity of Human Mesenchymal Stromal/Stem Cells. In: Birbrair, A. (eds) Stem Cells Heterogeneity - Novel Concepts. Advances in Experimental Medicine and Biology, vol 1123. Springer, Cham. https://doi.org/10.1007/978-3-030-11096-3_10

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