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Cellular and Molecular Detection of Multi-doses of Ionizing Radiation-Induced Immunomodulatory Response

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Abstract

Ionizing radiation (IR) is used in a wide range of clinical applications. The study aims to evaluate various IR doses for their immunomodulatory responses, which can be used in multiple immunological conditions. Forty rats were exposed to whole-body gamma rays of 0, 0.25, 0.5, and 1 Gray (Gy). T-cell receptor (TCR) gene expression, serum transforming growth factor-beta, interleukin-10 (IL-10), and nitric oxide levels were measured on days 1 and 4 post irradiation. TCR activation occurred only at the genetic level, and radiation raised all measured parameters, even at low doses at α = 0.05 (P < 0.05). Except for IL-10, it shows a nearly 6% (P < 0.05) rise in early response in irradiated groups up to 0.5 Gy. At lower doses, the indirect impacts of IR were as essential as the direct impacts, and they increased over time in most measured parameters due to endogenous releases. They were having an anti-proliferative effect on the immune system. Lastly, a single acute IR dose can raise anti-inflammatory cytokines and anti-proliferative effects in the immune system, avoiding various contraindications associated with immunomodulatory drugs. More information on safety and clinical relevance is needed.

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Authors and Affiliations

  1. Immunology lecturer, Radiation Safety Department, National Center for Nuclear Safety and Radiation Control, Egyptian Atomic Energy Authority/ Egyptian Nuclear and Radiological Regulatory Authority, 3 Ahmed Elzomor Str., 11762, P.O. Box 7551, Nasr City, Cairo, Egypt

    Soha M. Hussien

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Hussien, S.M. Cellular and Molecular Detection of Multi-doses of Ionizing Radiation-Induced Immunomodulatory Response. Cell Biochem Biophys 79, 887–894 (2021). https://doi.org/10.1007/s12013-021-01017-5

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