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Biodegradable Effect of PLGA Membrane in Alveolar Bone Regeneration on Beagle Dog

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Abstract

Guided bone regeneration (GBR) is a principle adopted from guided tissue regeneration (GTR). Wherein, GBR is used for the healing of peri-implant bony dehiscences, for the immediate placement of implants into extraction sockets and for the augmentation of atrophic alveolar ridges. This procedure is done by the placement of a resorbable or non-resorbable membrane that will exclude undesirable types of tissue growth between the extraction socket and the soft tissue to allow only bone cells to regenerate in the surgically treated lesion. Here, we investigated the biodegradable effect of polylactic-co-glycolic acid (PLGA) membrane in the alveolar bone on Beagle dogs. Results show that both collagen and PLGA membrane had been fully resorbed, biodegraded, at four weeks post-operative reentry into the alveolar bone. Histological results under light microscopy revealed formation of new bone trabeculae in the extraction sites on both collagen and PLGA membrane. In conclusion, PLGA membrane could be a potential biomaterials for use on GBR and GTR. Nevertheless, further studies will be necessary to elucidate the efficiency and cost effectiveness of PLGA as GBR membrane in clinical.

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Authors and Affiliations

  1. Department of Stomatology, Shanghai Yangsi Hospital, Shanghai, 200126, People’s Republic of China

    Nan Hua

  2. Shanghai Parkway Health Dental Clinic, Shanghai, 200040, People’s Republic of China

    Vivian Lao Ti

  3. Department of Stomatology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, 200126, People’s Republic of China

    Yuanzhi Xu

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  1. Nan Hua
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  2. Vivian Lao Ti
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  3. Yuanzhi Xu
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Correspondence to Yuanzhi Xu.

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Hua, N., Ti, V.L. & Xu, Y. Biodegradable Effect of PLGA Membrane in Alveolar Bone Regeneration on Beagle Dog. Cell Biochem Biophys 70, 1051–1055 (2014). https://doi.org/10.1007/s12013-014-0022-5

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  • DOI: https://doi.org/10.1007/s12013-014-0022-5

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